KIFC3 Antibody (D-9): sc-365494
- KIFC3 Antibody (D-9) is a mouse monoclonal IgG1 κ KIFC3 antibody provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of KIFC3 of human origin
- recommended for detection of KIFC3 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for KIFC3 Antibody (D-9) for WB applications. This reagent is now offered in a bundle with KIFC3 Antibody (D-9) (see ordering information below).
KIFC3 Antibody (D-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects KIFC3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KIFC3 antibody (D-9) is available as the non-conjugated monoclonal isotype antibody. KIFC3, or kinesin family member C3, is a vital motor protein composed of 833 amino acids that plays a significant role in intracellular transport and cellular organization. KIFC3 is primarily located in the cytoplasm and associates with the peripheral membrane, specifically found in the zona adherens of confluent epithelial cells and in renal distal tubules and the loops of Henle. Proper localization of KIFC3 is crucial for maintaining the integrity of the zona adherens, which is essential for cell-cell adhesion and tissue architecture. Additionally, KIFC3 is involved in apically targeted transport, ensuring that proteins and organelles are correctly distributed within the cell, which is vital for various cellular functions, including cell division and membrane trafficking. Encoded by a gene located on human chromosome 16q13, KIFC3′s function and localization underscore its importance in cellular dynamics and overall tissue health, making KIFC3 (D-9) antibody an invaluable tool for researchers studying these processes.
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KIFC3 Antibody (D-9) References:
- Characterization of a novel C-kinesin (KIFC3) abundantly expressed in vertebrate retina and RPE. | Hoang, E., et al. 1999. Exp Eye Res. 69: 57-68. PMID: 10375449
- KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes. | Noda, Y., et al. 2001. J Cell Biol. 155: 77-88. PMID: 11581287
- Role of KIFC3 motor protein in Golgi positioning and integration. | Xu, Y., et al. 2002. J Cell Biol. 158: 293-303. PMID: 12135985
- Mapping of transcription start sites of human retina expressed genes. | Roni, V., et al. 2007. BMC Genomics. 8: 42. PMID: 17286855
- Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. | Meng, W., et al. 2008. Cell. 135: 948-59. PMID: 19041755
- Overexpression of kinesins mediates docetaxel resistance in breast cancer cells. | De, S., et al. 2009. Cancer Res. 69: 8035-42. PMID: 19789344
- Multiple kinesin family members expressed in teleost retina and RPE include a novel C-terminal kinesin. | Bost-Usinger, L., et al. 1997. Exp Eye Res. 64: 781-94. PMID: 9245909
- Cloning of a novel C-terminal kinesin (KIFC3) that maps to human chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl syndrome. | Hoang, EH., et al. 1998. Genomics. 52: 219-22. PMID: 9782090
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KIFC3 Antibody (D-9) | sc-365494 | 200 µg/ml | $316.00 | |||
KIFC3 Antibody (D-9): m-IgG Fc BP-HRP Bundle | sc-525884 | 200 µg Ab; 10 µg BP | $354.00 |