KIFC1 Antibody (M-63): sc-100947

KIFC1 Antibody (M-63) is a mouse monoclonal IgG2a kappa light chain antibody that detects KIFC1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-KIFC1 antibody (M-63) is available as the non-conjugated format. KIFC1, also known as kinesin family member C1, HSET, or KNSL2, is a 673 amino acid protein that plays a pivotal role in organizing microtubules during cell division. KIFC1 is primarily located in the nucleus and features a C-terminal kinesin-motor domain, which is essential for function as a minus-end directed microtubule-dependent motor. KIFC1 interacts with NuMA and cytoplasmic Dynein to facilitate the organization of microtubule minus ends at spindle poles, a critical process for ensuring proper bipolar spindle formation. Disruption of KIFC1 function in HeLa cells leads to the formation of multipolar mitotic spindles, highlighting importance in maintaining the fidelity of cell division. KIFC1′s ability to regulate intracellular transport and spindle organization underscores significance in cellular processes, making anti-KIFC1 antibody (M-63) an invaluable tool for researchers studying mitotic mechanisms and kinesin-related transport pathways.

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KIFC1 Antibody (M-63) References:

1. Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS).  |  Janitz, K., et al. 1999. Immunogenetics. 49: 644-52. PMID: 10369922
2. Molecular motors and their role in membrane traffic.  |  Hamm-Alvarez, SF. 1998. Adv Drug Deliv Rev. 29: 229-242. PMID: 10837592
3. A mutant of the motor protein kinesin that moves in both directions on microtubules.  |  Endow, SA. and Higuchi, H. 2000. Nature. 406: 913-6. PMID: 10972296
4. Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3.  |  Yang, Z., et al. 2001. Mol Cell Biol. 21: 765-70. PMID: 11154264
5. Kinesin-II, the heteromeric kinesin.  |  Cole, DG. 1999. Cell Mol Life Sci. 56: 217-26. PMID: 11212349
6. C-terminal kinesin motor KIFC1 participates in acrosome biogenesis and vesicle transport.  |  Yang, WX. and Sperry, AO. 2003. Biol Reprod. 69: 1719-29. PMID: 12826589
7. The molecular motor KIFC1 associates with a complex containing nucleoporin NUP62 that is regulated during development and by the small GTPase RAN.  |  Yang, WX., et al. 2006. Biol Reprod. 74: 684-90. PMID: 16371587
8. Loss of function of Saccharomyces cerevisiae kinesin-related CIN8 and KIP1 is suppressed by KAR3 motor domain mutations.  |  Hoyt, MA., et al. 1993. Genetics. 135: 35-44. PMID: 8224825
9. Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region.  |  Ando, A., et al. 1994. Immunogenetics. 39: 194-200. PMID: 8276466

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIFC1 Antibody (M-63) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-KIFC1 Antibody (M-63) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIFC1 Antibody (M-63) Specifications

Alternate Product Name: KIFC1

Product Clone Name: M-63

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 53-152

Epitope Target: KIFC1

Epitope Species: human

Product Reactivity/Detection: KIFC1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for KIFC1 Antibody (M-63): N/A