KIF3A Antibody (E-5): sc-376680

KIF3A Antibody (E-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects KIF3A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KIF3A antibody (E-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KIF3A protein is a vital member of the kinesin family, which comprises microtubule-dependent motor proteins essential for intracellular transport. KIF3A plays a significant role in the anterograde transport of membrane-bound organelles, particularly in neurons and melanosomes, and is crucial for the transport of protein complexes within cilia and flagella, which are necessary for their proper morphogenesis. KIF3A function is particularly important in neurogenesis, where KIF3A influences embryonic cellular events, including the determination of the left-right axis. Disruption of KIF3A function in photoreceptors has been linked to apoptotic cell death, underscoring the necessity of kinesin II-mediated transport for maintaining cell fate and overall cellular health. With diverse applications and critical role in cellular processes, KIF3A (E-5) antibody is an invaluable tool for researchers studying motor protein dynamics and their implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

KIF3A Antibody (E-5) References:

1. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II.  |  Marszalek, JR., et al. 1999. Proc Natl Acad Sci U S A. 96: 5043-8. PMID: 10220415
2. Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis.  |  Takeda, S., et al. 1999. J Cell Biol. 145: 825-36. PMID: 10330409
3. Molecular motors and their role in membrane traffic.  |  Hamm-Alvarez, SF. 1998. Adv Drug Deliv Rev. 29: 229-242. PMID: 10837592
4. Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3.  |  Yang, Z., et al. 2001. Mol Cell Biol. 21: 765-70. PMID: 11154264
5. Stirring up development with the heterotrimeric kinesin KIF3.  |  Hirokawa, N. 2000. Traffic. 1: 29-34. PMID: 11208056
6. Kinesin-II, the heteromeric kinesin.  |  Cole, DG. 1999. Cell Mol Life Sci. 56: 217-26. PMID: 11212349
7. Functional analysis of mouse kinesin motor Kif3C.  |  Yang, Z., et al. 2001. Mol Cell Biol. 21: 5306-11. PMID: 11463814
8. Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells.  |  Boehlke, C., et al. 2013. PLoS One. 8: e62165. PMID: 23658710
9. KIF3A is essential for sperm tail formation and manchette function.  |  Lehti, MS., et al. 2013. Mol Cell Endocrinol. 377: 44-55. PMID: 23831641
10. KIF3a promotes proliferation and invasion via Wnt signaling in advanced prostate cancer.  |  Liu, Z., et al. 2014. Mol Cancer Res. 12: 491-503. PMID: 24413182
11. KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer.  |  Kim, M., et al. 2016. Sci Rep. 6: 32770. PMID: 27596264
12. KIF3A regulates the Wnt/β-catenin pathway via transporting β-catenin during spermatogenesis in Eriocheir sinensis.  |  Liang, YJ., et al. 2020. Cell Tissue Res. 381: 527-541. PMID: 32458081

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIF3A Antibody (E-5) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-KIF3A Antibody (E-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIF3A Antibody (E-5) Specifications

Alternate Product Name: KIF3A

Product Clone Name: E-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 548-702

Epitope Target: KIF3A

Epitope Species: human

Product Reactivity/Detection: KIF3A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for KIF3A Antibody (E-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin