KIF3A Antibody (28): sc-135960
- KIF3A Antibody (28) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against amino acids 563-671 of KIF3A of human origin
- recommended for detection of KIF3A of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for KIF3A Antibody (28). This work is in progress.
KIF3A Antibody (28) is a mouse monoclonal IgG1 antibody that detects KIF3A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). KIF3A is a vital member of the kinesin family, specifically involved in the transport of membrane-bound organelles and protein complexes within cilia and flagella, which are essential for cellular motility and signaling. The proper functioning of KIF3A is crucial for neurogenesis, particularly during embryonic development, where KIF3A plays a role in the asymmetric distribution of cellular components that determine the left-right axis. Disruption of KIF3A function has been linked to significant cellular consequences, including apoptotic cell death in photoreceptors, highlighting KIF3A′s importance in maintaining cellular integrity and function. KIF3A′s interactions with other proteins, such as KIF3B and KIF3C, further underscore KIF3A′s role in orchestrating complex intracellular transport mechanisms, making anti-KIF3A antibody (28) an invaluable tool for researchers studying cellular transport processes and their implications in health and disease.
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KIF3A Antibody (28) References:
- Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia. | Qiu, N., et al. 2012. J Cell Sci. 125: 1945-57. PMID: 22357948
- Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. | Kodani, A., et al. 2013. EMBO J. 32: 597-607. PMID: 23386061
- Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens. | Giridhar, PV., et al. 2016. J Immunol. 197: 4228-4239. PMID: 27794000
- KIF3A knockdown sensitizes bronchial epithelia to apoptosis and aggravates airway inflammation in asthma. | Geng, G., et al. 2018. Biomed Pharmacother. 97: 1349-1355. PMID: 29156524
- KIF3A inhibits nasopharyngeal carcinoma proliferation, migration and invasion by interacting with β-catenin to suppress its nuclear accumulation. | Hu, Z., et al. 2022. Am J Cancer Res. 12: 5226-5240. PMID: 36504907
- Ac-SDKP promotes KIF3A-mediated β-catenin suppression through a ciliary mechanism to constrain silica-induced epithelial-myofibroblast transition. | Liu, S., et al. 2023. Biomed Pharmacother. 166: 115411. PMID: 37651800
- Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem cells. | Liu, R., et al. 2023. Cell Mol Biol (Noisy-le-grand). 69: 84-88. PMID: 37715417
- KIF3A tail domain phosphorylation is not required for ciliogenesis in mouse embryonic fibroblasts. | Fasawe, AS., et al. 2024. iScience. 27: 109149. PMID: 38405607
- Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis. | Liu, JC., et al. 2024. Cell Mol Life Sci. 81: 168. PMID: 38587639
- The heterotrimeric kinesin-2 family member KIF3A directly binds to disabled-1 (Dab1). | Kim, MH., et al. 2024. BMB Rep. 57: 447-452. PMID: 38919020
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KIF3A Antibody (28) | sc-135960 | 50 µg/0.5 ml | $316.00 |