KIF12 Antibody (E-8): sc-376809

KIF12 Antibody (E-8) is a mouse monoclonal IgG1 antibody that detects KIF12 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KIF12 is a kinesin-like protein consisting of 651 amino acids, playing a crucial role in mitotically linked cytokinesis, which is essential for proper cell division. KIF12 is vital for the localization of myosin II during mitosis and is involved in the separation of nuclei during late anaphase and telophase, ensuring that daughter cells receive the correct genetic material. The structure of KIF12 includes a KISc domain, a coiled-coil domain with an internal hinge region, and a C-terminal tail domain, which are important for motor activity and interaction with microtubules. The precise arrangement of these domains allows KIF12 to effectively transport cellular components, thereby influencing various cellular processes, including neuronal function and development. KIF12 mRNA is expressed in several tissues, including fetal liver, adult brain, pancreatic islet, and is notably present in kidney tumors as well as uterine and pancreatic cancers, highlighting potential as a biomarker for these conditions. Anti-KIF12 antibody (E-8) is an invaluable tool for researchers studying the dynamics of cell division and the role of kinesins in cellular transport mechanisms.

The preferred KIF12 antibody is KIF12 Antibody (C-4): sc-376572.