KIBRA Antibody (B-3): sc-518263
- KIBRA Antibody (B-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1017-1042 of KIBRA of human origin
- recommended for detection of KIBRA of human origin by WB, IP, IF and ELISA
- Anti-KIBRA Antibody (B-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
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KIBRA Antibody (B-3) is an IgG1 kappa mouse monoclonal KIBRA antibody (also designated KIBRA antibody) that detects KIBRA of human origin by WB, IP, IF and ELISA. KIBRA Antibody (B-3) is available as the non-conjugated anti-KIBRA antibody form, as well as multiple conjugated forms of anti-KIBRA antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. KIBRA (kidney and brain protein), also known as WWC1 (WW and C2 domain containing 1) or HBEBP3, is a 1,113 amino acid protein that localizes to the cytoplasm and contains one C2 domain and two WW domains. Expressed in colon, brain, kidney and heart tissue, KIBRA is thought to interact with dendrin and, via this interaction, may play a role in collagen-induced signaling. Additionally, KIBRA, which exists as multiple alternatively spliced isoforms, is involved in memory performance and in the pathogenesis of Alzheimer′s disease. The gene encoding KIBRA maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KIBRA Antibody (B-3) References:
- Characterization of KIBRA, a novel WW domain-containing protein. | Kremerskothen, J., et al. 2003. Biochem Biophys Res Commun. 300: 862-7. PMID: 12559952
- KIBRA is a novel substrate for protein kinase Czeta. | Büther, K., et al. 2004. Biochem Biophys Res Commun. 317: 703-7. PMID: 15081397
- Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. | Rayala, SK., et al. 2006. J Biol Chem. 281: 19092-9. PMID: 16684779
- Common Kibra alleles are associated with human memory performance. | Papassotiropoulos, A., et al. 2006. Science. 314: 475-8. PMID: 17053149
- KIBRA gene variants are associated with episodic memory in healthy elderly. | Schaper, K., et al. 2008. Neurobiol Aging. 29: 1123-5. PMID: 17353070
- KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. | Hilton, HN., et al. 2008. Biochim Biophys Acta. 1783: 383-93. PMID: 18190796
- KIBRA genetic polymorphism influences episodic memory in later life, but does not increase the risk of mild cognitive impairment. | Almeida, OP., et al. 2008. J Cell Mol Med. 12: 1672-6. PMID: 18194457
- Evidence for an association between KIBRA and late-onset Alzheimer's disease. | Corneveaux, JJ., et al. 2010. Neurobiol Aging. 31: 901-9. PMID: 18789830
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KIBRA Antibody (B-3) | sc-518263 | 200 µg/ml | $322.00 | |||
KIBRA Antibody (B-3): m-IgG1 BP-HRP Bundle | sc-551788 | 200 µg Ab; 20 µg BP | $361.00 | |||
KIBRA Antibody (B-3) AC | sc-518263 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KIBRA Antibody (B-3) HRP | sc-518263 HRP | 200 µg/ml | $322.00 | |||
KIBRA Antibody (B-3) FITC | sc-518263 FITC | 200 µg/ml | $336.00 | |||
KIBRA Antibody (B-3) PE | sc-518263 PE | 200 µg/ml | $349.00 | |||
KIBRA Antibody (B-3) Alexa Fluor® 488 | sc-518263 AF488 | 200 µg/ml | $364.00 | |||
KIBRA Antibody (B-3) Alexa Fluor® 546 | sc-518263 AF546 | 200 µg/ml | $364.00 | |||
KIBRA Antibody (B-3) Alexa Fluor® 594 | sc-518263 AF594 | 200 µg/ml | $364.00 | |||
KIBRA Antibody (B-3) Alexa Fluor® 647 | sc-518263 AF647 | 200 µg/ml | $364.00 | |||
KIBRA Antibody (B-3) Alexa Fluor® 680 | sc-518263 AF680 | 200 µg/ml | $364.00 | |||
KIBRA Antibody (B-3) Alexa Fluor® 790 | sc-518263 AF790 | 200 µg/ml | $364.00 |