KHNYN Antibody (E-3): sc-514168

KHNYN Antibody (E-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects KHNYN protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KHNYN (E-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KHNYN, also known as KH and NYN domain-containing protein or KIAA0323, is a 678 amino acid protein that plays a crucial role in cellular processes, particularly in RNA binding and regulation of gene expression. KHNYN′s ability to interact with RNA is vital for various cellular functions, including mRNA splicing and stability, which are essential for maintaining proper cellular function and response to environmental changes. Additionally, KHNYN undergoes significant post-translational modifications, including phosphorylation at specific serine and threonine residues, which can influence activity and interactions with other proteins. The gene encoding KHNYN is located on human chromosome 14, a region that harbors several important genes, including those associated with Alzheimer′s disease and α1-antitrypsin deficiency, highlighting the potential implications of KHNYN in various health conditions.

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KHNYN Antibody (E-3) References:

1. The DNA sequence and analysis of human chromosome 14.  |  Heilig, R., et al. 2003. Nature. 421: 601-7. PMID: 12508121
2. Pathological and physiological functions of presenilins.  |  Vetrivel, KS., et al. 2006. Mol Neurodegener. 1: 4. PMID: 16930451
3. Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population.  |  Albani, D., et al. 2007. Neurobiol Aging. 28: 1682-8. PMID: 16952411
4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.  |  Olsen, JV., et al. 2006. Cell. 127: 635-48. PMID: 17081983
5. Molecular cytogenetic characterization of t(14;19)(q32;p13), a new recurrent translocation in B cell malignancies.  |  Micci, F., et al. 2007. Virchows Arch. 450: 559-65. PMID: 17406891
6. A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation.  |  Martín-Subero, JI., et al. 2007. Leukemia. 21: 1532-44. PMID: 17495977
7. The genetics of very early onset Alzheimer disease.  |  Filley, CM., et al. 2007. Cogn Behav Neurol. 20: 149-56. PMID: 17846513
8. Alpha1-antitrypsin deficiency: current perspective on research, diagnosis, and management.  |  Stolk, J., et al. 2006. Int J Chron Obstruct Pulmon Dis. 1: 151-60. PMID: 18046892
9. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.  |  Nagase, T., et al. 1997. DNA Res. 4: 141-50. PMID: 9205841

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KHNYN Antibody (E-3) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-KHNYN Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KHNYN Antibody (E-3) Specifications

Alternate Product Name: KHNYN

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 93-292

Epitope Target: KHNYN

Epitope Species: human

Product Reactivity/Detection: KHNYN

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for KHNYN Antibody (E-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin