Kell Antibody (3H571): sc-71465

Kell Antibody (3H571) is a mouse monoclonal IgG1 antibody that detects Kell in human samples through immunoprecipitation (IP). Kell is a type II transmembrane endopeptidase encoded by the KEL (CD238) gene, which is part of a larger family of zinc-dependent endopeptidases. Kell (3H571) antibody recognizes a crucial surface antigen on red blood cells, where Kell links to the XK protein via a single disulfide bond. Kell expression is vital for maintaining red blood cell integrity, and Kell absence, as seen in the McLeod phenotype, can lead to significant clinical manifestations, including nerve and muscle disorders as well as red cell acanthocytosis. Kell (3H571) monoclonal antibody detects expression predominantly in erythroid tissues and testis, with lower levels found in various other tissues such as brain and lymphoid tissues. Notably, immunohistochemistry studies have shown Kell localization in Sertoli cells of the testis and follicular dendritic cells in the spleen and tonsil, highlighting Kell importance in both hematological and reproductive functions. Anti-Kell antibody (3H571) serves as an essential tool for researchers investigating Kell′s role in health and disease, particularly in studies related to blood group antigens and their associated clinical implications.

The preferred Kell antibody is Kell Antibody (A-10): sc-377199.