KCNRG Antibody (A-9): sc-390290
- KCNRG Antibody (A-9) is a mouse monoclonal IgG1 κ KCNRG antibody provided at 200 µg/ml
- raised against amino acids 11-189 mapping near the N-terminus of KCNRG of mouse origin
- KCNRG Antibody (A-9) is recommended for detection of KCNRG of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-KCNRG Antibody (A-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KCNRG Antibody (A-9) for WB and IHC(P) applications. These reagents are now offered in bundles with KCNRG Antibody (A-9) (see ordering information below).
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KCNRG Antibody (A-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects KCNRG protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). KCNRG (A-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KCNRG protein plays a crucial role in regulating potassium ion channels, specifically inhibiting potassium fluxes through Kv1.1 and Kv1.4 channels, which are essential for maintaining electrical excitability of neurons and muscle cells. This regulation is vital for proper neuronal signaling and muscle contraction, as KCNRG influences the repolarization phase of action potentials. KCNRG is located on human chromosome 13q, a region often associated with deletions that can lead to loss of tumor suppressor functions, resulting in gastrointestinal stromal tumors, hepatocellular carcinomas, and other soft tissue tumors. Additionally, autoantibodies against KCNRG have been implicated in pulmonary manifestations observed in patients with autoimmune polyendocrine syndrome type 1 (APS-1), highlighting KCNRG′s significance in both cancer biology and autoimmune disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KCNRG Antibody (A-9) References:
- A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3. | Ivanov, DV., et al. 2003. FEBS Lett. 539: 156-60. PMID: 12650944
- Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas. | Cho, YG., et al. 2006. Exp Mol Med. 38: 247-55. PMID: 16819283
- [Analysis of 13q14 chromosomal instability in soft tissue tumors by fluorescence in-situ hybridization]. | Zhou, WX., et al. 2007. Zhonghua Bing Li Xue Za Zhi. 36: 582-6. PMID: 18070444
- Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen. | Alimohammadi, M., et al. 2009. Proc Natl Acad Sci U S A. 106: 4396-401. PMID: 19251657
- Aberrations of chromosome 13q in gastrointestinal stromal tumors: analysis of 91 cases by fluorescence in situ hybridization (FISH). | Zhou, W., et al. 2009. Diagn Mol Pathol. 18: 72-80. PMID: 19430298
- Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels. | Usman, H. and Mathew, MK. 2010. Biochem Biophys Res Commun. 391: 1301-5. PMID: 19968958
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KCNRG Antibody (A-9) | sc-390290 | 200 µg/ml | $316.00 | |||
KCNRG Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-530121 | 200 µg Ab; 10 µg BP | $354.00 | |||
KCNRG Antibody (A-9): m-IgGκ BP-HRP Bundle | sc-523480 | 200 µg Ab, 40 µg BP | $354.00 | |||
KCNRG Antibody (A-9): m-IgG1 BP-HRP Bundle | sc-543879 | 200 µg Ab; 20 µg BP | $354.00 | |||
KCNRG Antibody (A-9) AC | sc-390290 AC | 500 µg/ml, 25% agarose | $416.00 | |||
KCNRG Antibody (A-9) HRP | sc-390290 HRP | 200 µg/ml | $316.00 | |||
KCNRG Antibody (A-9) FITC | sc-390290 FITC | 200 µg/ml | $330.00 | |||
KCNRG Antibody (A-9) PE | sc-390290 PE | 200 µg/ml | $343.00 | |||
KCNRG Antibody (A-9) Alexa Fluor® 488 | sc-390290 AF488 | 200 µg/ml | $357.00 | |||
KCNRG Antibody (A-9) Alexa Fluor® 546 | sc-390290 AF546 | 200 µg/ml | $357.00 | |||
KCNRG Antibody (A-9) Alexa Fluor® 594 | sc-390290 AF594 | 200 µg/ml | $357.00 | |||
KCNRG Antibody (A-9) Alexa Fluor® 647 | sc-390290 AF647 | 200 µg/ml | $357.00 | |||
KCNRG Antibody (A-9) Alexa Fluor® 680 | sc-390290 AF680 | 200 µg/ml | $357.00 | |||
KCNRG Antibody (A-9) Alexa Fluor® 790 | sc-390290 AF790 | 200 µg/ml | $357.00 |