KCNQ2 Antibody (C-4): sc-271852

KCNQ2 Antibody (C-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects KCNQ2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KCNQ2 (C-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KCNQ2 protein plays a crucial role in regulating neuronal excitability, as a component of voltage-gated potassium channels that help maintain resting membrane potential and repolarize membrane after action potentials. This function is vital for preventing excessive neuronal firing, which can lead to conditions such as epilepsy. Mutations in KCNQ2 gene are associated with benign familial neonatal convulsions, a genetic form of epilepsy that manifests in infancy, highlighting KCNQ2′s importance in maintaining proper electrical signaling in the brain. KCNQ2 protein is characterized by six transmembrane domains, which are essential for function as a potassium channel, and expression is widely distributed throughout the brain, often overlapping with KCNQ3, another potassium channel protein. This overlap suggests a collaborative role in modulating neuronal activity, making KCNQ2 a significant target for research into epilepsy and other neurological disorders.

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KCNQ2 Antibody (C-4) References:

1. Adult phenotype of KCNQ2 encephalopathy.  |  Boets, S., et al. 2022. J Med Genet. 59: 528-535. PMID: 33811133
2. Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.  |  Lopez, JP., et al. 2022. Neuron. 110: 2283-2298.e9. PMID: 35649415
3. KCNQ2-Related Epilepsy: Genotype-Phenotype Relationship with Tailored Antiseizure Medication (ASM)-A Systematic Review.  |  Falsaperla, R., et al. 2023. Neuropediatrics. 54: 297-307. PMID: 36948217
4. Precision Therapy in KCNQ2-Related Epilepsy.  |  Borggraefe, I. and Wagner, M. 2023. Neuropediatrics. 54: 295-296. PMID: 37722392
5. Ligand activation mechanisms of human KCNQ2 channel.  |  Ma, D., et al. 2023. Nat Commun. 14: 6632. PMID: 37857637
6. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns.  |  Singh, NA., et al. 1998. Nat Genet. 18: 25-9. PMID: 9425895
7. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family.  |  Charlier, C., et al. 1998. Nat Genet. 18: 53-5. PMID: 9425900
8. A potassium channel mutation in neonatal human epilepsy.  |  Biervert, C., et al. 1998. Science. 279: 403-6. PMID: 9430594
9. Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy.  |  Yang, WP., et al. 1998. J Biol Chem. 273: 19419-23. PMID: 9677360
10. The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3.  |  Tinel, N., et al. 1998. FEBS Lett. 438: 171-6. PMID: 9827540
11. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.  |  Wang, HS., et al. 1998. Science. 282: 1890-3. PMID: 9836639
12. Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy.  |  Schroeder, BC., et al. 1998. Nature. 396: 687-90. PMID: 9872318

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KCNQ2 Antibody (C-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-KCNQ2 Antibody (C-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KCNQ2 Antibody (C-4) Specifications

Alternate Product Name: KCNQ2

Product Clone Name: C-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 641-780

Epitope Target: KCNQ2

Epitope Species: human

Product Reactivity/Detection: KCNQ2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for KCNQ2 Antibody (C-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin