KCNE1 Antibody (G-10): sc-393575
- KCNE1 Antibody (G-10) is a mouse monoclonal IgG2a κ KCNE1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-123 mapping at the N-terminus of KCNE1 of mouse origin
- KCNE1 Antibody (G-10) is recommended for detection of KCNE1 of mouse and rat origin by WB, IP, IF and ELISA
- Anti-KCNE1 Antibody (G-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KCNE1 Antibody (G-10) for WB applications. These reagents are now offered in bundles with KCNE1 Antibody (G-10) (see ordering information below).
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KCNE1 Antibody (G-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects KCNE1 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KCNE1 (G-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KCNE1 protein plays a crucial role in regulating voltage-gated potassium channels, particularly in forming I_Kr channel, which is essential for cardiac repolarization. KCNE1 protein interacts with HERG channel, a key component of cardiac action potential, and proper function is vital for maintaining normal heart rhythm. Mutations in KCNE1 gene can lead to severe cardiac conditions, including congenital long QT syndrome, highlighting KCNE1′s importance in both cardiac health and disease. KCNE1 gene is located on chromosome 21, and expression is tightly regulated in various tissues, ensuring potassium ion flow is appropriately modulated during cellular excitability.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KCNE1 Antibody (G-10) References:
- MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. | Abbott, GW., et al. 1999. Cell. 97: 175-87. PMID: 10219239
- A constitutively open potassium channel formed by KCNQ1 and KCNE3. | Schroeder, BC., et al. 2000. Nature. 403: 196-9. PMID: 10646604
- A common polymorphism associated with antibiotic-induced cardiac arrhythmia. | Sesti, F., et al. 2000. Proc Natl Acad Sci U S A. 97: 10613-8. PMID: 10984545
- M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit. | Tinel, N., et al. 2000. FEBS Lett. 480: 137-41. PMID: 11034315
- KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. | Tinel, N., et al. 2000. EMBO J. 19: 6326-30. PMID: 11101505
- The cardiac K+ channel KCNQ1 is essential for gastric acid secretion. | Grahammer, F., et al. 2001. Gastroenterology. 120: 1363-71. PMID: 11313306
- Cloning of a membrane protein that induces a slow voltage-gated potassium current. | Takumi, T., et al. 1988. Science. 242: 1042-5. PMID: 3194754
- Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. | Wang, Q., et al. 1996. Nat Genet. 12: 17-23. PMID: 8528244
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KCNE1 Antibody (G-10) | sc-393575 | 200 µg/ml | $322.00 | |||
KCNE1 Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-530504 | 200 µg Ab; 10 µg BP | $361.00 | |||
KCNE1 Antibody (G-10): m-IgGκ BP-HRP Bundle | sc-524006 | 200 µg Ab, 40 µg BP | $361.00 | |||
KCNE1 Antibody (G-10): m-IgG2a BP-HRP Bundle | sc-547512 | 200 µg Ab; 10 µg BP | $361.00 | |||
KCNE1 Antibody (G-10) AC | sc-393575 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KCNE1 Antibody (G-10) HRP | sc-393575 HRP | 200 µg/ml | $322.00 | |||
KCNE1 Antibody (G-10) FITC | sc-393575 FITC | 200 µg/ml | $336.00 | |||
KCNE1 Antibody (G-10) PE | sc-393575 PE | 200 µg/ml | $349.00 | |||
KCNE1 Antibody (G-10) Alexa Fluor® 488 | sc-393575 AF488 | 200 µg/ml | $364.00 | |||
KCNE1 Antibody (G-10) Alexa Fluor® 546 | sc-393575 AF546 | 200 µg/ml | $364.00 | |||
KCNE1 Antibody (G-10) Alexa Fluor® 594 | sc-393575 AF594 | 200 µg/ml | $364.00 | |||
KCNE1 Antibody (G-10) Alexa Fluor® 647 | sc-393575 AF647 | 200 µg/ml | $364.00 | |||
KCNE1 Antibody (G-10) Alexa Fluor® 680 | sc-393575 AF680 | 200 µg/ml | $364.00 | |||
KCNE1 Antibody (G-10) Alexa Fluor® 790 | sc-393575 AF790 | 200 µg/ml | $364.00 |