KChIP2 Antibody (9K9): sc-134371
- KChIP2 Antibody (9K9) is a mouse monoclonal IgG1 κ KChIP2 antibody provided at 100 µg/ml
- raised against recombinant KChIP2 protein of human origin
- recommended for detection of KChIP2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for KChIP2 Antibody (9K9). This work is in progress.
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KChIP2 Antibody (9K9) is a mouse monoclonal IgG1 kappa light chain antibody that detects KChIP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-KChIP2 antibody (9K9) is available as a non-conjugated monoclonal isotype antibody. KChIP2 protein plays a crucial role in modulating voltage-gated potassium channels, particularly in brain and heart, where KChIP2 interacts with Kv4.2 subunits to regulate neuronal excitability and cardiac myocyte function. This interaction maintains proper electrical signaling in these tissues by influencing rapid inactivation of A-type potassium currents, essential for action potential repolarization. KChIP2 belongs to a larger family of KChIP proteins, including KChIP1 and KChIP3, which share significant nucleotide homology with DREAM, suggesting roles beyond Kv channel modulation. KChIP2′s presence in neocortical and subcortical structures highlights KChIP2′s importance in various neural processes, making anti-KChIP2 antibody (9K9) valuable for cardiac and neuronal research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
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KChIP2 Antibody (9K9) References:
- Modulation of A-type potassium channels by a family of calcium sensors. | An, WF., et al. 2000. Nature. 403: 553-6. PMID: 10676964
- Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. | Dixon, JE., et al. 1996. Circ Res. 79: 659-68. PMID: 8831489
- K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. | Hoffman, DA., et al. 1997. Nature. 387: 869-75. PMID: 9202119
- Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. | Buxbaum, JD., et al. 1998. Nat Med. 4: 1177-81. PMID: 9771752
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KChIP2 Antibody (9K9) | sc-134371 | 100 µg/ml | $339.00 |