KAT I Antibody (H-5): sc-166186

KAT I Antibody (H-5) is a mouse monoclonal IgG2a antibody that detects KAT I in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KAT I is a crucial cytoplasmic enzyme belonging to the class-I pyridoxal-phosphate-dependent aminotransferase family, playing a significant role in glutamine catabolism. KAT I (H-5) antibody catalyzes the transamination of L-kynurenine to produce kynurenic acid, a metabolite derived from tryptophan that exhibits neuroprotective and anticonvulsant properties. The importance of kynurenic acid lies in its involvement in synaptic transmission and its potential implications in various neurological disorders, including schizophrenia and Huntington′s disease. KAT I exists in three isoforms, with isoform 1 being the full-length protein, while isoform 2 and isoform 3 lack specific amino acid sequences. Notably, KAT I is believed to function as a homodimer based on sequence similarity, which may influence its enzymatic activity and interactions with other proteins. Anti-KAT I antibody (H-5) is an essential tool for researchers investigating the biochemical pathways involving kynurenine metabolism and its impact on neurological health.

The preferred KAT I antibody is KAT I Antibody (C-7): sc-374531.