karyopherin β1 Antibody (E-7): sc-365299

karyopherin β1 Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects karyopherin β1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Karyopherin β1 plays a crucial role in the nuclear transport system, functioning as an adapter that facilitates the import of various proteins into the nucleus by binding to karyopherin α1 and forming a complex that interacts with nucleoporins at the nuclear pore complex. This process is vital for maintaining cellular function, as karyopherin β1 regulates the localization of proteins essential for gene expression, cell cycle progression, and signal transduction. Karyopherin β1 function is particularly important in cellular responses to stress and regulation of transcription factors, which can influence cell growth and differentiation. Abnormalities in karyopherin β1 function have been implicated in various diseases, including cancer, highlighting its significance as a target for therapeutic intervention. Anti-karyopherin β1 antibody (E-7) serves as an invaluable tool for researchers studying nuclear transport mechanisms and their implications in health and disease.

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karyopherin β1 Antibody (E-7) References:

1. Impaired expression of importin/karyopherin beta1 leads to post-implantation lethality.  |  Miura, K., et al. 2006. Biochem Biophys Res Commun. 341: 132-8. PMID: 16414015
2. The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.  |  van der Watt, PJ., et al. 2009. Int J Cancer. 124: 1829-40. PMID: 19117056
3. Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15.  |  Di Girolamo, M. 2015. Curr Top Microbiol Immunol. 384: 189-209. PMID: 25037261
4. The importin protein karyopherin-β1 regulates the mice fibroblast-like synoviocytes inflammation via facilitating nucleus transportation of STAT3 transcription factor.  |  Sun, C., et al. 2016. Biochem Biophys Res Commun. 471: 553-9. PMID: 26879143
5. mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response.  |  Fonseca, D., et al. 2018. Mol Cell Biol. 38: PMID: 29180510
6. A tight balance of Karyopherin β1 expression is required in cervical cancer cells.  |  Carden, S., et al. 2018. BMC Cancer. 18: 1123. PMID: 30445944
7. Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region.  |  Verrico, A., et al. 2020. Oncogene. 39: 454-468. PMID: 31492900
8. Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines.  |  Hazawa, M., et al. 2020. Cancers (Basel). 12: PMID: 32276424
9. Tumor-promoting properties of karyopherin β1 in melanoma by stabilizing Ras-GTPase-activating protein SH3 domain-binding protein 1.  |  Yang, F., et al. 2022. Cancer Gene Ther. 29: 1939-1950. PMID: 35902727
10. Importin subunit beta-1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation.  |  Lombardi, Z., et al. 2025. Mol Oncol. 19: 99-113. PMID: 38965815

The preferred karyopherin β1 antibody is karyopherin β1 Antibody (H-7): sc-137016.