karyopherin β1 Antibody (23): sc-136226
- karyopherin β1 Antibody (23) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 48-241 of karyopherin β1 of rat origin
- recommended for detection of karyopherin β1 of mouse, rat, human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for karyopherin β1 Antibody (23). This work is in progress.
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karyopherin β1 Antibody (23) is a mouse monoclonal IgG1 antibody that detects karyopherin β1 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Karyopherin β1 plays a crucial role in the nuclear transport process, acting as an adapter that facilitates the docking of the karyopherin α1/substrate complex to nucleoporins at the nuclear pore complex. This interaction is vital for the selective import of proteins into the nucleus, ensuring that essential regulatory factors and signaling molecules are properly localized to maintain cellular function. Anti-karyopherin β1 antibody (23) is also involved in the import of specific RNA-binding proteins and ribosomal proteins, highlighting its multifaceted role in cellular homeostasis and gene expression regulation. Karyopherin β1 monoclonal antibody (23) serves as an invaluable tool for researchers studying nuclear transport mechanisms and the intricate pathways that govern cellular function and communication.
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karyopherin β1 Antibody (23) References:
- Impaired expression of importin/karyopherin beta1 leads to post-implantation lethality. | Miura, K., et al. 2006. Biochem Biophys Res Commun. 341: 132-8. PMID: 16414015
- The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. | van der Watt, PJ., et al. 2009. Int J Cancer. 124: 1829-40. PMID: 19117056
- Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein. | Desmond, CR., et al. 2012. J Biol Chem. 287: 39626-33. PMID: 23012356
- A tight balance of Karyopherin β1 expression is required in cervical cancer cells. | Carden, S., et al. 2018. BMC Cancer. 18: 1123. PMID: 30445944
- Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region. | Verrico, A., et al. 2020. Oncogene. 39: 454-468. PMID: 31492900
- Karyopherin β1 deletion suppresses tumor growth and metastasis in colorectal cancer (CRC) by reducing MET expression. | Zhang, Y. and Li, KF. 2019. Biomed Pharmacother. 120: 109127. PMID: 31629952
- Inhibition of NUPR1-Karyopherin β1 Binding Increases Anticancer Drug Sensitivity. | Park, C., et al. 2021. Int J Mol Sci. 22: PMID: 33801927
- Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer. | Kelenis, DP., et al. 2022. Cancer Res. 82: 3058-3073. PMID: 35748745
- Functional domains in nuclear import factor p97 for binding the nuclear localization sequence receptor and the nuclear pore. | Chi, NC. and Adam, SA. 1997. Mol Biol Cell. 8: 945-56. PMID: 9201707
- Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97. | Tiganis, T., et al. 1997. J Biol Chem. 272: 21548-57. PMID: 9261175
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
karyopherin β1 Antibody (23) | sc-136226 | 50 µg/0.5 ml | $316.00 |