karyopherin α2 Antibody (2G7): sc-57009
- karyopherin α2 Antibody (2G7) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against amino acids 116-515 of karyopherin α2 of human origin
- recommended for detection of karyopherin α2 of mouse, rat and human origin by WB and IP
- See karyopherin α2 (B-9): sc-55538 for karyopherin α2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for karyopherin α2 Antibody (2G7). This work is in progress.
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SEE ALSO...
karyopherin α2 Antibody (2G7) is a rat monoclonal IgG2a antibody that detects karyopherin α2 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Karyopherin α2 plays a crucial role in the nuclear import process by recognizing and binding to specific substrates, which is essential for the regulation of gene expression and cellular function. Karyopherin α2 is primarily located in the cytoplasm, where anti-karyopherin α2 antibody (2G7) can detect interactions with various nuclear localization signals on cargo proteins, facilitating their transport across the nuclear envelope. The importance of karyopherin α2′s function is underscored by its involvement in the import of viral proteins, such as the Epstein-Barr virus nuclear antigen 1 (EBNA1), which can influence viral replication and pathogenesis. Karyopherin α2 (2G7) antibody enables researchers to gain insights into the mechanisms of nuclear transport and the implications of dysregulation in various diseases, including cancer and viral infections.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
karyopherin α2 Antibody (2G7) References:
- Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells. | Guillemain, G., et al. 2002. Biochem J. 364: 201-9. PMID: 11988093
- A karyopherin alpha2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells. | Cassany, A., et al. 2004. Traffic. 5: 10-9. PMID: 14675421
- Karyopherin alpha2 is essential for rRNA transcription and protein synthesis in proliferative keratinocytes. | Umegaki-Arao, N., et al. 2013. PLoS One. 8: e76416. PMID: 24098495
- Silencing of karyopherin α2 inhibits cell growth and survival in human hepatocellular carcinoma. | Yang, Y., et al. 2017. Oncotarget. 8: 36289-36304. PMID: 28422734
- Inhibition of Karyopherin-α2 Augments Radiation-Induced Cell Death by Perturbing BRCA1-Mediated DNA Repair. | Song, KH., et al. 2019. Int J Mol Sci. 20: PMID: 31212646
- Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer. | Drucker, E., et al. 2019. Cell Commun Signal. 17: 159. PMID: 31783876
- Oncogenic role of karyopherin α2 (KPNA2) in human tumors: A pan-cancer analysis. | Sun, Y., et al. 2021. Comput Biol Med. 139: 104955. PMID: 34735944
- Overexpression of Karyopherin α2 in small cell carcinoma of the cervix correlates with poor prognosis. | Liao, LM., et al. 2022. Int J Clin Exp Pathol. 15: 241-246. PMID: 35795090
- Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2. | Sheng, JD., et al. 2023. J Physiol Pharmacol. 74: PMID: 38345447
- Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice. | Rother, F., et al. 2024. FASEB J. 38: e23623. PMID: 38656660
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
karyopherin α2 Antibody (2G7) | sc-57009 | 200 µg/ml | $316.00 |