karyopherin α2 Antibody (1A6): sc-101538

karyopherin α2 Antibody (1A6) is a rat monoclonal IgG2a antibody that detects karyopherin α2 in mouse, rat, human, and simian samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Karyopherin α2 plays a crucial role in the nuclear import process, specifically in recognizing and binding to substrates destined for transport into the nucleus. Karyopherin α2 is essential for the selective transport of various proteins, including transcription factors and other regulatory proteins, which are vital for maintaining cellular function and gene expression. Karyopherin α2′s ability to interact with specific substrates ensures that only appropriate proteins are imported, thereby regulating cellular processes such as cell cycle progression and response to stress. Karyopherin α2 has been shown to complex with Epstein-Barr virus nuclear antigen 1 (EBNA1), highlighting its importance not only in normal cellular function but also in viral pathogenesis. Precise localization of karyopherin α2 within the cytoplasm and dynamic interaction with the nuclear pore complex underscore its significance in nucleocytoplasmic transport, making anti-karyopherin α2 antibody (1A6) an invaluable tool for researchers studying these critical cellular mechanisms.

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karyopherin α2 Antibody (1A6) References:

1. Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells.  |  Guillemain, G., et al. 2002. Biochem J. 364: 201-9. PMID: 11988093
2. A karyopherin alpha2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells.  |  Cassany, A., et al. 2004. Traffic. 5: 10-9. PMID: 14675421
3. Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer.  |  Dahl, E., et al. 2006. Clin Cancer Res. 12: 3950-60. PMID: 16818692
4. The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.  |  Sandrock, K., et al. 2010. Traffic. 11: 198-209. PMID: 19961560
5. Silencing of karyopherin α2 inhibits cell growth and survival in human hepatocellular carcinoma.  |  Yang, Y., et al. 2017. Oncotarget. 8: 36289-36304. PMID: 28422734
6. Inhibition of Karyopherin-α2 Augments Radiation-Induced Cell Death by Perturbing BRCA1-Mediated DNA Repair.  |  Song, KH., et al. 2019. Int J Mol Sci. 20: PMID: 31212646
7. Oncogenic role of karyopherin α2 (KPNA2) in human tumors: A pan-cancer analysis.  |  Sun, Y., et al. 2021. Comput Biol Med. 139: 104955. PMID: 34735944
8. Overexpression of Karyopherin α2 in small cell carcinoma of the cervix correlates with poor prognosis.  |  Liao, LM., et al. 2022. Int J Clin Exp Pathol. 15: 241-246. PMID: 35795090
9. Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2.  |  Sheng, JD., et al. 2023. J Physiol Pharmacol. 74: PMID: 38345447
10. Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice.  |  Rother, F., et al. 2024. FASEB J. 38: e23623. PMID: 38656660

The preferred karyopherin α2 antibody is karyopherin α2 Antibody (B-9): sc-55538.