Kaiso Antibody (12H): sc-23930

Kaiso Antibody (12H) is a mouse monoclonal IgG1 antibody that detects Kaiso in mouse, rat, human, canine, avian, and hamster samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Kaiso, a member of the BTB/POZ family of zinc finger transcription factors, plays a crucial role in regulating gene expression during embryonic development and has been implicated in various cancers. Kaiso is primarily localized in the nucleus, where anti-Kaiso antibody (12H) can detect its function as a transcriptional repressor, particularly in neural tissues, highlighting Kaiso′s importance in the development of the central nervous system. Kaiso contains a unique amino-terminal BTB-POZ domain that facilitates protein-protein interactions, along with three carboxy-terminal zinc finger domains that specifically bind to symmetrically methylated DNA sequences, thereby influencing gene regulation. Notably, Kaiso interacts with p120 catenin, a protein essential for maintaining cell adhesion and signaling pathways, further underscoring Kaiso′s significance in cellular processes. Kaiso monoclonal antibody (12H) serves as an invaluable tool for researchers studying Kaiso′s intricate roles in development and disease, providing insights into its function and potential as a therapeutic target.

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Kaiso Antibody (12H) References:

1. Cytoplasmic Kaiso is associated with poor prognosis in non-small cell lung cancer.  |  Dai, SD., et al. 2009. BMC Cancer. 9: 178. PMID: 19508730
2. The transcriptional repressor Kaiso localizes at the mitotic spindle and is a constituent of the pericentriolar material.  |  Soubry, A., et al. 2010. PLoS One. 5: e9203. PMID: 20169156
3. Kaiso represses the cell cycle gene cyclin D1 via sequence-specific and methyl-CpG-dependent mechanisms.  |  Donaldson, NS., et al. 2012. PLoS One. 7: e50398. PMID: 23226276
4. Kaiso interacts with p120-catenin to regulate β-catenin expression at the transcriptional level.  |  Liu, Y., et al. 2014. PLoS One. 9: e87537. PMID: 24498333
5. Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation.  |  Bohne, F., et al. 2016. Clin Epigenetics. 8: 47. PMID: 27152123
6. Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells.  |  Bassey-Archibong, BI., et al. 2017. Cell Death Dis. 8: e2689. PMID: 28333150
7. DeSUMOylation switches Kaiso from activator to repressor upon hyperosmotic stress.  |  Zhenilo, S., et al. 2018. Cell Death Differ. 25: 1938-1951. PMID: 29472715
8. Kaiso-induced intestinal inflammation is preceded by diminished E-cadherin expression and intestinal integrity.  |  Robinson, SC., et al. 2019. PLoS One. 14: e0217220. PMID: 31199830
9. Canonical Kaiso target genes define a functional signature that associates with breast cancer survival and the invasive lobular carcinoma histological type.  |  Sijnesael, T., et al. 2023. J Pathol. 261: 477-489. PMID: 37737015
10. Dissecting the Kaiso binding profile in clear renal cancer cells.  |  Starshin, A., et al. 2024. Epigenetics Chromatin. 17: 38. PMID: 39702290

The preferred Kaiso antibody is Kaiso Antibody (6F8): sc-23871.