JZL 184
Application:
JZL 184 is an irreversible inhibitor of Monoglyceride Lipase (monoacylglycerol lipase, MAGL)
Molecular Weight:
520.49
Molecular Formula:
C27H24N2O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
JZL184 is an irreversible inhibitor of Monoglyceride Lipase (monoacylglycerol lipase, MAGL), the primary enzyme responsible for degrading the endocannabinoid 2-arachidonoylglycerol (2-AG).
JZL 184 References
- Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. | Pan, B., et al. 2009. J Pharmacol Exp Ther. 331: 591-7. PMID: 19666749
- Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. | Chang, JW., et al. 2012. Chem Biol. 19: 579-88. PMID: 22542104
- The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model. | Ghosh, S., et al. 2013. Life Sci. 92: 498-505. PMID: 22749865
- Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. | Wise, LE., et al. 2012. ACS Chem Neurosci. 3: 369-78. PMID: 22860205
- Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597. | Crow, JA., et al. 2012. Biochem Pharmacol. 84: 1215-22. PMID: 22943979
- The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. | Kerr, DM., et al. 2013. Br J Pharmacol. 169: 808-19. PMID: 23043675
- Monoacylglycerol lipase inhibitor, JZL-184, confers neuroprotection in the mice middle cerebral artery occlusion model of stroke. | Rahmani, MR., et al. 2018. Life Sci. 198: 143-148. PMID: 29496497
- JZL184, as a monoacylglycerol lipase inhibitor, down-regulates inflammation in a cannabinoid pathway dependent manner. | Rahmani, MR., et al. 2018. Biomed Pharmacother. 103: 1720-1726. PMID: 29864962
- Monoacylglycerol Lipase Inhibitor is Safe when Combined with Delayed r-tPA Administration in Treatment of Stroke. | Rahmani, MR., et al. 2018. Inflammation. 41: 2052-2059. PMID: 30047001
- Increased 2-arachidonoyl-sn-glycerol levels normalize cortical responses to sound and improve behaviors in Fmr1 KO mice. | Pirbhoy, PS., et al. 2021. J Neurodev Disord. 13: 47. PMID: 34645383
Inhibitor of:
Monoglyceride Lipase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JZL 184, 5 mg | sc-300854 | 5 mg | $122.00 |