Junctophilin-2 Antibody (D-11): sc-398457
- Junctophilin-2 Antibody (D-11) is a mouse monoclonal IgG3 provided at 200 µg/ml
- specific for an epitope mapping between amino acids 554-579 near the C-terminus of Junctophilin-2 of human origin
- recommended for detection of Junctophilin-2 isoform 1 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Junctophilin-2 Antibody (D-11). This work is in progress.
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Junctophilin-2 Antibody (D-11) is a mouse monoclonal IgG3 antibody that detects Junctophilin-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Junctophilin-2 plays a crucial role in the formation of junctional complexes between the plasma membrane and the endoplasmic reticulum, which is essential for the proper functioning of excitable cells, particularly in cardiac and skeletal muscle tissues. Junctophilin-2 facilitates the organization of calcium signaling microdomains, thereby influencing calcium homeostasis and excitation-contraction coupling. Disruption of Junctophilin-2 function can lead to severe cardiac dysfunction, as evidenced by studies on mutant mice lacking the Jph2 gene, which exhibit embryonic lethality and abnormal calcium transients in cardiac myocytes. Anti-Junctophilin-2 antibody (D-11) is an invaluable tool for researchers investigating the molecular mechanisms underlying muscle physiology and pathophysiology, as well as for exploring potential therapeutic targets in related diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Junctophilin-2 Antibody (D-11) | sc-398457 | 200 µg/ml | $322.00 | |||
Junctophilin-2 (D-11) Neutralizing Peptide | sc-398457 P | 100 µg/0.5 ml | $69.00 |