JRKL Antibody (73-Q): sc-100971
- JRKL Antibody (73-Q) is a mouse monoclonal IgG1 κ provided at 50 µg/0.5 ml
- raised against recombinant JRKL of human origin
- recommended for detection of JRKL of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for JRKL Antibody (73-Q). This work is in progress.
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JRKL Antibody (73-Q) is a mouse monoclonal IgG1 antibody that detects JRKL in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-JRKL antibody (73-Q) recognizes JRKL, a 442 amino acid protein predominantly localized in the nucleus, suggesting a potential role in nuclear processes. JRKL expression is notably high across various tissues, although less prevalent in the liver, lung, and peripheral blood leukocytes. This widespread expression pattern may indicate involvement in critical biological functions, including those related to neuronal activity and development. JRKL shares 35% homology with the mouse JRK protein, which has been implicated in the pathogenesis of epilepsy when inactivated, highlighting JRKL′s potential significance in neurological disorders. The presence of a DDE domain and an HTH CENPB-type DNA-binding domain in JRKL suggests a possible role in DNA binding, which could be crucial for gene regulation or chromatin remodeling. Anti-JRKL antibody (73-Q) effectively detects JRKL across multiple species and applications, making this reagent an invaluable tool for researchers studying molecular mechanisms underlying epilepsy and related conditions.
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JRKL Antibody (73-Q) References:
- NRK-dependent phosphorylation of NAB-3: involvement in ACRK-13-mediated PUFFL activation or NEE-JRK activation of ACRO. | Eaton, JW. and Hunt, NH. 2001. Redox Rep. 6: 131. PMID: 11523585
- Identification of the Genomic Insertion Site of the Thyroid Peroxidase Promoter-Cre Recombinase Transgene Using a Novel, Efficient, Next-Generation DNA Sequencing Method. | Raman, P., et al. 2015. Thyroid. 25: 1162-6. PMID: 26179797
- JRK is a positive regulator of β-catenin transcriptional activity commonly overexpressed in colon, breast and ovarian cancer. | Pangon, L., et al. 2016. Oncogene. 35: 2834-41. PMID: 26455321
- Genetic Analysis with the Immunochip Platform in Behçet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci. | Ortiz-Fernández, L., et al. 2016. PLoS One. 11: e0161305. PMID: 27548383
- Evolution of pogo, a separate superfamily of IS630-Tc1-mariner transposons, revealing recurrent domestication events in vertebrates. | Gao, B., et al. 2020. Mob DNA. 11: 25. PMID: 32742312
- Anti-inflammatory effect of trans-anethol in a rat model of myocardial ischemia-reperfusion injury. | Matboli, M., et al. 2022. Biomed Pharmacother. 150: 113070. PMID: 35658236
- Assessing the Immune Cell Subset and Genetic Mutations in Patients With Palindromic Rheumatism Seronegative for Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide. | Yang, CA., et al. 2023. Arthritis Rheumatol. 75: 187-200. PMID: 35819819
- Reorganization of 3D chromatin architecture in doxorubicin-resistant breast cancer cells. | Wang, X., et al. 2022. Front Cell Dev Biol. 10: 974750. PMID: 36003143
- JRK binds satellite III DNA and is necessary for the heat shock response. | Waldron, R., et al. 2024. Cell Biol Int. 48: 1212-1222. PMID: 38946594
- Genetics in Behcet's Disease: An Update Review. | Gao, Y., et al. 2022. Front Ophthalmol (Lausanne). 2: 916887. PMID: 38983559
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JRKL Antibody (73-Q) | sc-100971 | 50 µg/0.5 ml | $333.00 |