JRAB Antibody (G-10): sc-376791

JRAB Antibody (G-10) is a mouse monoclonal IgG2a antibody that detects JRAB (junctional Rab13-binding protein, MICAL-like protein 2) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JRAB is a 904 amino acid protein characterized by one calponin-homology (CH) domain and one LIM zinc-binding domain, playing a crucial role in cellular transport processes by interacting with Rab13 and Rab8 to facilitate the movement of key proteins like claudin-1, occludin, and E-cadherin. This interaction is essential for the proper assembly of tight junctions (TJs) and adherens junctions (AJs), which are critical for maintaining epithelial integrity and function. The dynamic turnover of these junctions, particularly through endocytic recycling, is vital for epithelial morphogenesis during development and differentiation. Furthermore, JRAB and Rab13 have been implicated in the metastatic behavior of carcinoma cells, as JRAB and Rab13 colocalize with F-Actin in lamellipodial structures prior to the scattering of epithelial cells, highlighting their importance in cancer progression. JRAB Antibody (G-10) serves as an invaluable tool for researchers studying cell junction dynamics and their implications in health and disease.

The preferred JRAB antibody is JRAB Antibody (F-5): sc-376675.