Josephin-3 Antibody (C-3): sc-515159

Josephin-3 Antibody (C-3) is a mouse monoclonal IgG2b antibody that detects Josephin-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Josephin-3, also known as TATA box-binding protein-associated factor RNA polymerase I subunit D, is a crucial 278 amino acid transcription factor encoded by the human TAF1D gene. Josephin-3 plays a vital role in the assembly of the SL1 complex, which is essential for the formation of the preinitiation complex necessary for RNA polymerase I-dependent transcription. The SL1 complex not only stabilizes the nucleolar transcription factor 1/UBTF on ribosomal DNA but also ensures proper cell cycle progression, particularly through G2/M phase-specific phosphorylations. Josephin-3 is expressed across various tissues, where Josephin-3 is predominantly localized in the nucleus, highlighting its central role in regulating gene expression and maintaining cellular function. Anti-Josephin-3 antibody (C-3) is an invaluable tool for researchers studying transcriptional regulation and its implications in cellular processes.

The preferred Josephin-3 antibody is Josephin-3 Antibody (G-12): sc-514821.