JNK3 Antibody (4G6): sc-81469

JNK3 Antibody (4G6) is a mouse monoclonal IgG1 antibody raised against the N-terminus of human JNK3, a crucial stress-activated protein kinase involved in neuronal signaling. JNK3 mouse monoclonal antibody (4G6) recognizes an epitope within the N-terminal region and demonstrates broad species cross-reactivity, detecting JNK3 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. Unlike other JNK family members, JNK3 shows predominant expression in neurons, where JNK3 plays sophisticated roles in stress response and programmed cell death pathways. This neuron-specific distribution makes JNK3 particularly significant in neurodegenerative conditions such as Alzheimer′s disease, where JNK3 contributes to pathological processes through two main mechanisms: promoting neuronal cell death and phosphorylating tau protein, which can lead to neurofibrillary tangle formation. JNK3′s activity undergoes precise regulation through post-translational modifications, particularly phosphorylation, which modulates both JNK3′s catalytic activity and ability to interact with various signaling partners. Beyond neurological functions, JNK3 responds to pro-inflammatory cytokines and environmental stressors, coordinating cellular adaptive responses. The significance of JNK3 extends to cancer biology, where alterations in JNK3 signaling can influence cell proliferation and survival in various malignancies, including breast and lung cancer. Through these diverse cellular roles and disease implications, JNK3 (4G6) antibody serves as a valuable tool for investigating both neurological disorders and cancer mechanisms, potentially leading to the development of targeted therapeutic strategies.

The preferred p-JNK antibody is p-JNK Antibody (G-7): sc-6254.