JMJD2A Antibody (H-8): sc-373850
- JMJD2A Antibody (H-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 347-633 mapping within an internal region of JMJD2A of human origin
- recommended for detection of JMJD2A of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for JMJD2A Antibody (H-8) for WB applications. This reagent is now offered in a bundle with JMJD2A Antibody (H-8) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
JMJD2A Antibody (H-8) is a mouse monoclonal IgG1 antibody that detects JMJD2A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JMJD2A, also known as jumonji domain containing 2A, is a 1,064 amino acid protein encoded by the human gene JMJD2A and is a member of the JHDM3 histone demethylase family. JMJD2A plays a crucial role in gene expression regulation by specifically demethylating lysine residues 9 and 36 on histone H3, essential for proper interpretation of the histone code. JMJD2A′s ability to demethylate tri-methylated H3 Lys 9 and H3 Lys 36, while leaving other residues untouched, highlights JMJD2A′s specificity and importance in chromatin remodeling and transcriptional regulation. JMJD2A generates formaldehyde and succinate as byproducts of demethylation activity, which can have further implications in cellular metabolism and signaling pathways. JMJD2A is ubiquitously expressed in the nucleus, where JMJD2A participates in transcriptional repression by recruiting histone deacetylases and the nuclear receptor co-repressor 1 (NCOR1) to specific promoters, thereby influencing the expression of genes such as ASCL2 and E2F-responsive targets. Anti-JMJD2A antibody (H-8) is an invaluable tool for researchers studying epigenetic regulation and the dynamics of histone modifications in various biological contexts.
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JMJD2A Antibody (H-8) References:
- The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. | Zhang, QJ., et al. 2011. J Clin Invest. 121: 2447-56. PMID: 21555854
- JMJD2A predicts prognosis and regulates cell growth in human gastric cancer. | Hu, CE., et al. 2014. Biochem Biophys Res Commun. 449: 1-7. PMID: 24802408
- Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. | Kim, TD., et al. 2016. J Clin Invest. 126: 706-20. PMID: 26731476
- SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication. | Yang, WS., et al. 2017. PLoS Pathog. 13: e1006216. PMID: 28212444
- HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372. | An, J., et al. 2017. Oncotarget. 8: 49093-49109. PMID: 28467776
- JMJD2A facilitates growth and inhibits apoptosis of cervical cancer cells by downregulating tumor suppressor miR‑491‑5p. | Li, Y., et al. 2019. Mol Med Rep. 19: 2489-2496. PMID: 30720092
- Upregulation of JMJD2A promotes migration and invasion in bladder cancer through regulation of SLUG. | Wang, F., et al. 2019. Oncol Rep. 42: 1431-1440. PMID: 31364745
- JMJD2A promotes the development of castration-resistant prostate cancer by activating androgen receptor enhancer and inhibiting the cGAS-STING pathway. | Cai, X., et al. 2024. Mol Carcinog. 63: 1682-1696. PMID: 38818897
- The role of JMJD2A in immune evasion and malignant behavior of esophageal squamous cell carcinoma. | Su, X., et al. 2024. Int Immunopharmacol. 137: 112401. PMID: 38878485
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JMJD2A Antibody (H-8) | sc-373850 | 200 µg/ml | $322.00 | |||
JMJD2A Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-535318 | 200 µg Ab; 40 µg BP | $361.00 |