JIP-1 Antibody (50): sc-135957
- JIP-1 Antibody (50) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 180-384 of JIP-1 of mouse origin
- recommended for detection of JIP-1 of mouse and rat origin by WB and IP
- See JIP-1 (B-7): sc-25267 for JIP-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for JIP-1 Antibody (50). This work is in progress.
JIP-1 Antibody (50) is a mouse monoclonal IgG1 antibody that detects JIP-1 in mouse and rat samples through western blotting (WB) and immunoprecipitation (IP) applications. JIP-1, also known as JNK interacting protein-1, plays a crucial role in regulating the c-Jun NH2-terminal kinase (JNK) signaling pathway, which is vital for cellular responses to stress, including apoptosis and inflammation. By binding to JNK, JIP-1 acts as a cytoplasmic inhibitor, sequestering JNK in the cytoplasm and preventing JNK activation of downstream target genes such as c-Jun and ATF-2. This interaction helps maintain cellular homeostasis and prevents excessive activation of stress response pathways that could lead to pathological conditions. Multiple splice variants of JIP-1, including JIP-1b and JIP-1c, add another layer of complexity to JIP-1 regulatory functions, especially in the brain, where these variants may have distinct roles in neuronal signaling and plasticity. Anti-JIP-1 antibody (50) serves as an essential tool for researchers studying the intricate mechanisms of JNK signaling and its implications in various diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JIP-1 Antibody (50) | sc-135957 | 50 µg/0.5 ml | $322.00 |