Jaw1 Antibody (D-12): sc-390207
- Jaw1 Antibody (D-12) is a mouse monoclonal IgG1 κ Jaw1 antibody provided at 200 µg/ml
- raised against a peptide mapping at the N-terminus of Jaw1 of human origin
- Jaw1 Antibody (D-12) is recommended for detection of Jaw1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Jaw1 Antibody (D-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Jaw1 Antibody (D-12) for WB applications. This reagent is now offered in a bundle with Jaw1 Antibody (D-12) (see ordering information below).
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Jaw1 Antibody (D-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects Jaw1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Jaw1 (D-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Jaw1, a type II membrane protein, is primarily localized to the endoplasmic reticulum, where Jaw1 plays a crucial role in lymphoid cell development regulation. Jaw1 expression is specifically restricted to lymphoid B and T cell lineages and notably down-regulated during terminal differentiation, highlighting Jaw1′s importance in immune system function. Jaw1 protein sequence shows significant similarity to MRVI1, which is specifically expressed in megakaryocytes, suggesting potential functional parallels. Jaw1 undergoes post-translational modifications at the carboxyl terminus, essential for endoplasmic reticulum association, where Jaw1 co-localizes with ER marker BiP. Additionally, a coiled-coil domain in the middle third and a conserved 36-amino acid lumenal tail at the carboxy-terminus underscore Jaw1′s structural significance, as these features likely mediate protein-protein interactions and ensure proper cellular localization. Given Jaw1′s expression patterns and localization, Jaw1 is implicated in antigen receptor assembly and trafficking regulation during lymphoid development, making Jaw1 a vital component in the adaptive immune response.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Jaw1 Antibody (D-12) References:
- Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. | Shaughnessy, JD., et al. 1999. Oncogene. 18: 2069-84. PMID: 10321731
- Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulum. | Behrens, TW., et al. 1994. J Immunol. 153: 682-90. PMID: 8021504
- Carboxyl-terminal targeting and novel post-translational processing of JAW1, a lymphoid protein of the endoplasmic reticulum. | Behrens, TW., et al. 1996. J Biol Chem. 271: 23528-34. PMID: 8798562
- The transmembrane domain of a carboxyl-terminal anchored protein determines localization to the endoplasmic reticulum. | Yang, M., et al. 1997. J Biol Chem. 272: 1970-5. PMID: 8999888
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Jaw1 Antibody (D-12) | sc-390207 | 200 µg/ml | $322.00 | |||
Jaw1 Antibody (D-12): m-IgG Fc BP-HRP Bundle | sc-526131 | 200 µg Ab; 10 µg BP | $361.00 | |||
Jaw1 Antibody (D-12) AC | sc-390207 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Jaw1 Antibody (D-12) HRP | sc-390207 HRP | 200 µg/ml | $322.00 | |||
Jaw1 Antibody (D-12) FITC | sc-390207 FITC | 200 µg/ml | $336.00 | |||
Jaw1 Antibody (D-12) PE | sc-390207 PE | 200 µg/ml | $349.00 | |||
Jaw1 Antibody (D-12) Alexa Fluor® 488 | sc-390207 AF488 | 200 µg/ml | $364.00 | |||
Jaw1 Antibody (D-12) Alexa Fluor® 546 | sc-390207 AF546 | 200 µg/ml | $364.00 | |||
Jaw1 Antibody (D-12) Alexa Fluor® 594 | sc-390207 AF594 | 200 µg/ml | $364.00 | |||
Jaw1 Antibody (D-12) Alexa Fluor® 647 | sc-390207 AF647 | 200 µg/ml | $364.00 | |||
Jaw1 Antibody (D-12) Alexa Fluor® 680 | sc-390207 AF680 | 200 µg/ml | $364.00 | |||
Jaw1 Antibody (D-12) Alexa Fluor® 790 | sc-390207 AF790 | 200 µg/ml | $364.00 | |||
Jaw1 (D-12) Neutralizing Peptide | sc-390207 P | 100 µg/0.5 ml | $69.00 |