JAM-A Antibody (M.Ab.F11): sc-52690
- JAM-A Antibody (M.Ab.F11) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- recommended for detection of JAM-A of human origin by WB, IP and FCM
- See JAM-A (J10.4): sc-53623 for JAM-A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for JAM-A Antibody (M.Ab.F11). This work is in progress.
JAM-A Antibody (M.Ab.F11) is a mouse monoclonal IgG1 light chain antibody recommended for the detection of JAM-A of human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Junctional Adhesion Molecule A (JAM-A), also known as JAM-1 or F11 Receptor (F11R), is a member of the immunoglobulin superfamily prominently located at tight junctions of epithelial and endothelial cells. JAM-A′s localization at these tight junctions is crucial because JAM-A mediates cell-cell adhesion through homophilic interactions, contributing to the integrity and selective permeability of cellular barriers. JAM-A plays a vital role in regulating paracellular permeability and maintaining cell polarity, which is essential for tissue homeostasis and function. Additionally, JAM-A is constitutively expressed on circulating monocytes, neutrophils, lymphocyte subsets, and platelets, highlighting JAM-A′s significant role in the immune system. JAM-A associates with F-actin at cell-cell contacts and membrane ruffles, influencing cytoskeletal organization and cellular motility. By modulating leukocyte extravasation, JAM-A is implicated in the transendothelial migration of leukocytes during inflammatory responses. Anti-JAM-A antibody (M.Ab.F11) offers researchers a specific and reliable tool to study JAM-A′s function in cellular adhesion, tight junction organization, and immune cell trafficking, thereby advancing our understanding of physiological processes and potential therapeutic targets.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAM-A Antibody (M.Ab.F11) | sc-52690 | 100 µg/ml | $322.00 |