JAM-A Antibody (H202-106): sc-59845

JAM-A Antibody (H202-106) is a rat monoclonal IgG1 antibody raised against JAM-A from MTE1/MTE2 stromal cell lines of mouse origin. Junctional Adhesion Molecule A (JAM-A), also known as JAM-1 or F11 Receptor (F11R), is a member of the immunoglobulin superfamily expressed in tight junctions of epithelial and endothelial cells. JAM-A plays a critical role in cell-cell adhesion through homophilic interactions, contributing to the organization of tight junctions and regulating paracellular permeability. JAM-A is involved in the transendothelial migration of leukocytes, making JAM-A essential for immune cell trafficking and inflammatory responses. JAM-A is constitutively expressed on circulating monocytes, neutrophils, lymphocyte subsets, and platelets, indicating JAM-A′s widespread role in the immune system. By localizing with F-actin at cell-cell contacts and membrane ruffles, JAM-A influences cytoskeletal organization and cellular motility. Understanding JAM-A function is important for elucidating mechanisms underlying vascular permeability, inflammation, and leukocyte extravasation. JAM-A (H202-106) monoclonal antibody is reactive with JAM-A of mouse origin by immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM), making JAM-A (H202-106) antibody a valuable tool for studying JAM-A function in various biological contexts. The JAM family also includes JAM-B (JAM-2) and JAM-C (JAM-3), which interact with each other and play roles in lymphocyte trafficking and inflammation. Anti-JAM-A antibody (H202-106) aids in advancing research on cell adhesion, immune cell migration, and potential therapeutic interventions for inflammatory diseases.

The preferred JAM-A antibody is JAM-A Antibody (J10.4): sc-53623.