JAM-A Antibody (BV12): sc-52688
- JAM-A Antibody (BV12) is a rat monoclonal IgG2a, cited in 4 publications, provided at 200 µg/ml
- raised against H5V endothelial cells of mouse origin
- recommended for detection of JAM-A of mouse origin by IF and FCM; non cross-reactive with other JAM family members
- available conjugated to FITC for IF, IHC(P) and FCM
- See JAM-A (J10.4): sc-53623 for JAM-A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for JAM-A Antibody (BV12). This work is in progress.
JAM-A Antibody (BV12) is a rat monoclonal IgG2a antibody raised against H5V endothelial cells of mouse origin, specifically recognizing JAM-A of mouse origin by immunofluorescence (IF) and flow cytometry (FCM), and is non-cross-reactive with other JAM family members. Junctional Adhesion Molecule A (JAM-A), also known as JAM-1 or F11 Receptor (F11R), is a member of the immunoglobulin superfamily prominently located at tight junctions of epithelial and endothelial cells. JAM-A′s localization at tight junctions facilitates cell-cell adhesion through homophilic interactions, contributing to the integrity and permeability of cellular barriers. JAM-A′s presence at these junctions maintains cell polarity and regulates paracellular transport, which is important for tissue homeostasis. JAM-A is constitutively expressed on circulating monocytes, neutrophils, lymphocyte subsets, and platelets, indicating a significant role in the immune system. JAM-A localizes with F-actin at cell-cell contacts and membrane ruffles, influencing cytoskeletal organization and cellular motility. Through modulating leukocyte extravasation, JAM-A plays a pivotal role in inflammatory responses. Anti-JAM-A antibody (BV12) offers researchers a highly specific and reliable tool to study JAM-A′s function in cellular adhesion and immune cell trafficking, advancing our understanding of physiological processes and potential therapeutic targets.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAM-A Antibody (BV12) | sc-52688 | 200 µg/ml | $322.00 | |||
JAM-A Antibody (BV12) FITC | sc-52688 FITC | 200 µg/ml | $336.00 |