JAM-A Antibody (43): sc-135956
- JAM-A Antibody (43) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 126-237 of JAM-A of human origin
- recommended for detection of JAM-A of human origin by WB and IP
- See JAM-A (J10.4): sc-53623 for JAM-A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for JAM-A Antibody (43). This work is in progress.
JAM-A Antibody (43) is a mouse monoclonal IgG1 antibody raised against amino acids 126-237 of human JAM-A, specifically reactive with human JAM-A in western blotting (WB) and immunoprecipitation (IP) applications. Junctional Adhesion Molecule A (JAM-A), also known as JAM-1 or F11 Receptor (F11R), is a type I transmembrane protein belonging to the immunoglobulin superfamily and is prominently expressed at tight junctions of epithelial and endothelial cells. Structurally, JAM-A consists of two extracellular immunoglobulin-like domains that facilitate homophilic and heterophilic interactions essential for cell-cell adhesion and signaling. JAM-A′s cytoplasmic tail contains a PDZ-binding motif that interacts with scaffold proteins like ZO-1, AF-6, and PAR-3, linking JAM-A to the actin cytoskeleton and intracellular signaling pathways. JAM-A undergoes post-translational modifications such as phosphorylation and glycosylation, which are crucial for localization, stability, and function in maintaining tight junction integrity. JAM-A interacts with integrins like LFA-1 (CD11a/CD18) on leukocytes, facilitating leukocyte transmigration during immune responses, and is constitutively expressed on circulating monocytes, neutrophils, lymphocyte subsets, and platelets, highlighting JAM-A′s significant role in the immune system. JAM-A′s function in regulating paracellular permeability and leukocyte extravasation is vital for vascular permeability and inflammatory processes. Understanding JAM-A′s post-translational modifications, structure, and protein-protein interactions is important for elucidating mechanisms underlying tissue homeostasis, immune cell trafficking, and potential therapeutic targets for inflammatory diseases. Anti-JAM-A antibody (43) aids researchers in advancing our understanding of cellular adhesion, tight junction integrity, and immune responses.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAM-A Antibody (43) | sc-135956 | 50 µg/0.5 ml | $322.00 |