Jagged2 Antibody (F-4): sc-515725

Jagged2 Antibody (F-4) is a mouse monoclonal IgM kappa antibody that detects Jagged2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Jagged2 (F-4) antibody is available as a non-conjugated format, providing researchers with a reliable tool for studying this critical protein. Jagged2, a member of the LIN-12/Notch family of transmembrane receptors, plays a pivotal role in developmental processes by influencing cell fate decisions. Jagged2 protein is primarily located in the cell membrane, where Jagged2 functions as a ligand for Notch receptors, thereby activating signaling pathways essential for various biological processes, including cardiovascular development and hematopoiesis. The interaction between Jagged2 and Notch is crucial, as this interaction not only regulates cell differentiation but also prevents myoblasts from maturing into muscle cells by inhibiting muscle-specific genes. Jagged2 expression is notably up-regulated in certain pathological conditions, such as cervical squamous cell carcinoma, highlighting Jagged2′s potential role in tumorigenesis. Mutations in the JAG1 gene, which encodes Jagged2, have been linked to Familial Tetralogy of Fallot, the most prevalent form of complex congenital heart disease, underscoring Jagged2′s importance in both normal development and disease states.

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Jagged2 Antibody (F-4) References:

1. Fifteen novel mutations in the JAGGED1 gene of patients with Alagille syndrome.  |  Crosnier, C., et al. 2001. Hum Mutat. 17: 72-3. PMID: 11139247
2. Familial Tetralogy of Fallot caused by mutation in the jagged1 gene.  |  Eldadah, ZA., et al. 2001. Hum Mol Genet. 10: 163-9. PMID: 11152664
3. Expression of Notch1 and Jagged2 in the enteric nervous system.  |  Sander, GR., et al. 2003. J Histochem Cytochem. 51: 969-72. PMID: 12810847
4. Jagged2 promotes the development of natural killer cells and the establishment of functional natural killer cell lines.  |  DeHart, SL., et al. 2005. Blood. 105: 3521-7. PMID: 15650053
5. Th2 differentiation is unaffected by Jagged2 expression on dendritic cells.  |  Krawczyk, CM., et al. 2008. J Immunol. 180: 7931-7. PMID: 18523256
6. P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis.  |  Guo, M., et al. 2012. Front Biosci (Elite Ed). 4: 2631-44. PMID: 22652674
7. High expression of Notch ligand Jagged2 is associated with the metastasis and recurrence in urothelial carcinoma of bladder.  |  Li, W., et al. 2013. Int J Clin Exp Pathol. 6: 2430-40. PMID: 24228105
8. Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer.  |  Yang, M., et al. 2020. Br J Cancer. 123: 1404-1416. PMID: 32778818
9. Jagged: a mammalian ligand that activates Notch1.  |  Lindsell, CE., et al. 1995. Cell. 80: 909-17. PMID: 7697721
10. dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line.  |  Laborda, J., et al. 1993. J Biol Chem. 268: 3817-20. PMID: 8095043
11. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.  |  Luo, B., et al. 1997. Mol Cell Biol. 17: 6057-67. PMID: 9315665
12. JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions.  |  Valsecchi, C., et al. 1997. Mech Dev. 69: 203-7. PMID: 9486542

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Jagged2 Antibody (F-4) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Jagged2 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Jagged2 Antibody (F-4) Specifications

Alternate Product Name: JAG2

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1149-1171

Epitope Target: Jagged2

Epitope Species: rat

Product Reactivity/Detection: Jagged2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Jagged2 Antibody (F-4): N/A