ITM2B Antibody (H-11): sc-374214
- ITM2B Antibody (H-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-54 mapping at the N-terminus of ITM2B of human origin
- recommended for detection of ITM2B (Integral membrane protein 2B) of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ITM2B Antibody (H-11) for WB applications. These reagents are now offered in bundles with ITM2B Antibody (H-11) (see ordering information below).
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ITM2B Antibody (H-11) is a mouse monoclonal IgG1 antibody that detects ITM2B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ITM2B is a 266 amino acid protein that plays a crucial role in cellular signaling and membrane dynamics, particularly within the brain, where ITM2B is predominantly expressed. ITM2B features a potential N-glycosylation site and a single transmembrane-spanning domain, which are essential for proper localization and function in the cell membrane. Mutations in the ITM2B gene are linked to familial British dementia and familial Danish dementia, both autosomal dominant disorders that manifest with severe neurological symptoms, including dementia and ataxia. ITM2B′s ability to interact with other proteins involved in neurodegenerative processes underscores ITM2B′s significance in maintaining neuronal health and highlights anti-ITM2B antibody (H-11) as a valuable tool for studying these critical pathways in human health and disease.
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ITM2B Antibody (H-11) References:
- Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. | Martin, L., et al. 2008. J Biol Chem. 283: 1644-1652. PMID: 17965014
- Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells. | Tai, TS., et al. 2014. PLoS One. 9: e96535. PMID: 24831988
- The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases. | Baron, BW., et al. 2015. Biochim Biophys Acta. 1852: 742-8. PMID: 25557390
- G-MDSCs-Derived Exosomal miRNA-143-3p Promotes Proliferation via Targeting of ITM2B in Lung Cancer. | Zhou, JH., et al. 2020. Onco Targets Ther. 13: 9701-9719. PMID: 33061450
- A slit-diaphragm-associated protein network for dynamic control of renal filtration. | Kocylowski, MK., et al. 2022. Nat Commun. 13: 6446. PMID: 36307401
- Autoantibodies involved in primary and secondary adrenal insufficiency following treatment with immune checkpoint inhibitors. | Helderman, NC., et al. 2023. Immunooncol Technol. 17: 100374. PMID: 36937704
- MicroRNA-196a-5p facilitates the onset and progression via targeting ITM2B in esophageal squamous cell carcinoma. | Xian, D., et al. 2024. Pathol Int. 74: 129-138. PMID: 38289121
- Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis. | Lee, S., et al. 2024. Cell Rep. 43: 114146. PMID: 38676926
- Exosomal miR-196a-5p contributes to esophageal squamous cell carcinoma malignant progression by inhibiting ITM2B. | Huang, M., et al. 2024. Pathol Int. 74: 464-474. PMID: 38940569
- Genetic inference and single cell expression analysis of potential targets in heart failure and breast cancer. | Li, Y., et al. 2024. J Cancer Res Clin Oncol. 150: 479. PMID: 39460820
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ITM2B Antibody (H-11) | sc-374214 | 200 µg/ml | $322.00 | |||
ITM2B Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-537936 | 200 µg Ab; 10 µg BP | $361.00 | |||
ITM2B Antibody (H-11): m-IgGκ BP-HRP Bundle | sc-535421 | 200 µg Ab; 40 µg BP | $361.00 | |||
ITM2B Antibody (H-11): m-IgG1 BP-HRP Bundle | sc-545458 | 200 µg Ab; 20 µg BP | $361.00 |