ITI-H4 Antibody (A-12): sc-515242

ITI-H4 Antibody (A-12) is a mouse monoclonal IgG2a antibody that detects ITI-H4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ITI-H4 is a unique member of the inter-α-trypsin inhibitor (ITI) family, characterized by its single-chain structure, which distinguishes ITI-H4 from other multi-polypeptide members of the family. This structural uniqueness is significant as ITI-H4 may confer distinct functional properties, potentially influencing its role in various physiological processes. The gene encoding human ITI-H4 is located on chromosome 3p21.1, and ITI-H4 expression patterns differ markedly from those of rat ITI-H4, suggesting species-specific functions that are crucial for understanding biological roles in humans. The ITI family, including ITI-H4, plays a vital role in regulating protease activity and stabilizing the pericellular matrix through interactions with hyaluronic acid, which is essential for maintaining tissue integrity and modulating inflammatory responses. Anti-ITI-H4 antibody (A-12) enables researchers to explore the intricate functions of ITI-H4 and its implications in health and disease.

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ITI-H4 Antibody (A-12) References:

1. Liquid chromatography/tandem mass spectrometric method for the quantification of eight proteolytic fragments of ITIH4 with biomarker potential in human plasma and serum.  |  van den Broek, I., et al. 2008. Rapid Commun Mass Spectrom. 22: 2915-28. PMID: 18752334
2. Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma.  |  Noh, CK., et al. 2014. Clin Biochem. 47: 1257-61. PMID: 24836184
3. Site-specific glycan microheterogeneity of inter-alpha-trypsin inhibitor heavy chain H4.  |  Chandler, KB., et al. 2014. J Proteome Res. 13: 3314-29. PMID: 24884609
4. Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia.  |  Sira, MM., et al. 2014. Hepat Res Treat. 2014: 307942. PMID: 25295185
5. Schizophrenia risk variants in ITIH4 and CALN1 regulate gene expression in the dorsolateral prefrontal cortex.  |  Ohi, K., et al. 2016. Psychiatr Genet. 26: 142-3. PMID: 26991396
6. Levels of inter-alpha-trypsin inhibitor heavy chain H4 urinary polypeptide in gestational diabetes mellitus.  |  Hu, Z., et al. 2021. Syst Biol Reprod Med. 67: 428-437. PMID: 34607479
7. Longitudinal Change of Serum Inter-α-Trypsin Inhibitor Heavy Chain H4 and its Relation with Inflammation, Disease Recurrence, and Mortality in Acute Ischemic Stroke Patients.  |  Zhang, J., et al. 2023. Tohoku J Exp Med. 259: 221-227. PMID: 36596502
8. Longitudinal change of serum inter-alpha-trypsin inhibitor heavy chain H4, and its correlation with inflammation, multiorgan injury, and death risk in sepsis.  |  Zhao, X., et al. 2023. J Clin Lab Anal. 37: e24834. PMID: 36725250
9. Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis.  |  Ravindran, A., et al. 2024. Cardiovasc Res. 120: 869-882. PMID: 38289873
10. ITIH4 is a predictor for coronary thrombus in coronary arteriography patients.  |  Tian, L., et al. 2024. Future Cardiol. 20: 547-554. PMID: 39041488

The preferred ITI-H4 antibody is ITI-H4 Antibody (G-2): sc-515060.