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Isoproterenol Hydrochloride (CAS 51-30-9)

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Alternate Names:
Isoprenaline hydrochloride
Application:
Isoproterenol Hydrochloride is a selective β-adrenergic agonist
CAS Number:
51-30-9
Purity:
≥97%
Molecular Weight:
247.72
Molecular Formula:
C11H17NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Isoproterenol Hydrochloride is a phenethylamine derivative and selective beta-AR adrenergic agonist shown to increase cytosolic cAMP. Isoproterenol hydrochloride exhibits promotion of glycogen breakdown and causes bronchodilation and vasorelaxant effects. Also potentially stimulates relaxation in nitric oxide mediated endothelium-dependent smooth muscle. Isoproterenol Hydrochloride is an activator of beta2-AR and ERK.


Isoproterenol Hydrochloride (CAS 51-30-9) References

  1. beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf.  |  Schmitt, JM. and Stork, PJ. 2000. J Biol Chem. 275: 25342-50. PMID: 10840035
  2. A comparative study of atropine sulfate and isoproterenol hydrochloride in chronic bronchitis.  |  Klock, LE., et al. 1975. Am Rev Respir Dis. 112: 371-6. PMID: 1099948
  3. Extended Stability of Epinephrine Hydrochloride Injection in Polyvinyl Chloride Bags Stored in Amber Ultraviolet Light-Blocking Bags.  |  Van Matre, ET., et al. 2017. Hosp Pharm. 52: 570-573. PMID: 29276291
  4. Synthesis, isolation, identification and characterization of new process-related impurity in isoproterenol hydrochloride by HPLC, LC/ESI-MS and NMR.  |  Kumar, N., et al. 2017. J Pharm Anal. 7: 394-400. PMID: 29404065
  5. Forskolin modulates cyclic AMP generation in the rat myometrium. Interactions with isoproterenol and prostaglandins E2 and I2.  |  Mokhtari, A., et al. 1985. J Cyclic Nucleotide Protein Phosphor Res. 10: 213-27. PMID: 2991348
  6. Pyrroloquinoline quinone attenuates isoproterenol hydrochloride‑induced cardiac hypertrophy in AC16 cells by inhibiting the NF‑κB signaling pathway.  |  Wen, J., et al. 2020. Int J Mol Med. 45: 873-885. PMID: 31922230
  7. Circular RNA expression in isoproterenol hydrochloride-induced cardiac hypertrophy.  |  Yang, MH., et al. 2020. Aging (Albany NY). 12: 2530-2544. PMID: 32023551
  8. Isoproterenol increases Cl diffusion potential difference of rabbit trachea through nitric oxide generation.  |  Takemura, H., et al. 1995. J Pharmacol Exp Ther. 274: 584-8. PMID: 7616448
  9. Subtype-specific differences in the intracellular sorting of G protein-coupled receptors.  |  von Zastrow, M., et al. 1993. J Biol Chem. 268: 763-6. PMID: 7678260
  10. Isoproterenol inhibits cyclic AMP-mediated but not insulin-mediated translocation of the GLUT4 glucose transporter isoform.  |  Macaulay, SL., et al. 1994. Mol Cell Biochem. 141: 27-33. PMID: 7877606
  11. Natriuretic peptide clearance receptor is transcriptionally down-regulated by beta 2-adrenergic stimulation in vascular smooth muscle cells.  |  Kishimoto, I., et al. 1994. J Biol Chem. 269: 28300-8. PMID: 7961768
  12. Changes in microsomal lysophospholipid acyltransferase activity are correlated with rat parotid gland enlargement induced by chronic administration of isoproterenol.  |  Yashiro, K., et al. 1994. J Biochem. 115: 1040-6. PMID: 7982879
  13. Endothelins stimulate c-fos and nerve growth factor expression in astrocytes and astrocytoma.  |  Ladenheim, RG., et al. 1993. J Neurochem. 60: 260-6. PMID: 8417145

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Isoproterenol Hydrochloride, 100 mg

sc-202188
100 mg
$27.00

Isoproterenol Hydrochloride, 500 mg

sc-202188A
500 mg
$37.00