Islet-2 Antibody (203C5a): sc-130648
- Islet-2 Antibody (203C5a) is a mouse monoclonal IgG2b provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of Islet-2 of human origin
- recommended for detection of Islet-2 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Islet-2 Antibody (203C5a). This work is in progress.
Islet-2 Antibody (203C5a) is a mouse monoclonal IgG2b antibody that detects Islet-2 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. Islet-2 is a crucial nuclear protein composed of 359 amino acids, encoded by the human gene ISL2, and plays a significant role as a transcription factor in motor neuron development. Islet-2 features two N-terminal LIM domains, a homeodomain, and a serine/glutamine/threonine-rich C-terminus, which are essential for defining subclasses of motor neurons that organize into distinct columns within the spinal cord and select specific axon pathways. Islet-2 expression initially occurs in all postmitotic spinal motor neurons before differentiation into somatic and visceral neuronal fates. Somatic motor neurons retain Islet-2 expression during later embryonic stages, while visceral motor neurons require an early phase of Islet-2 expression for full character development. Mutations diminishing or abolishing both Islet-1 and Islet-2 activity can lead to severe defects in visceral motor neuron generation and compromised somatic motor neuron identity. Anti-Islet-2 antibody (203C5a) serves as an invaluable tool for researchers studying motor neuron development and related pathologies.
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Islet-2 Antibody (203C5a) References:
- Cloning and analysis of axolotl ISL2 and LHX2 LIM-homeodomain transcription factors. | Showalter, AD., et al. 2004. Genesis. 38: 110-21. PMID: 15048808
- Cloning and expression of a novel human gene, Isl-2, encoded a LIM-homeodomain protein. | Li, Y., et al. 2007. Mol Biol Rep. 34: 19-26. PMID: 17091338
- An essential RNA element resides in a central region of hepatitis E virus ORF2. | Emerson, SU., et al. 2013. J Gen Virol. 94: 1468-1476. PMID: 23515023
- Stress Survival Islet 2, Predominantly Present in Listeria monocytogenes Strains of Sequence Type 121, Is Involved in the Alkaline and Oxidative Stress Responses. | Harter, E., et al. 2017. Appl Environ Microbiol. 83: PMID: 28625982
- Mass Spectrometric Analysis of Proteins of L6 Skeletal Muscle Cells Under Different Glucose Conditions and Vitamin D Supplementation. | Taneja, N. and Priyadarshini,. 2018. Protein Pept Lett. 25: 356-361. PMID: 29623822
- ISL2 modulates angiogenesis through transcriptional regulation of ANGPT2 to promote cell proliferation and malignant transformation in oligodendroglioma. | Qi, L., et al. 2020. Oncogene. 39: 5964-5978. PMID: 32753650
- The U2AF2 /circRNA ARF1/miR-342-3p/ISL2 feedback loop regulates angiogenesis in glioma stem cells. | Jiang, Y., et al. 2020. J Exp Clin Cancer Res. 39: 182. PMID: 32894165
- ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer. | Ozturk, H., et al. 2022. Dev Cell. 57: 1331-1346.e9. PMID: 35508175
- Transcriptional control of motor pool formation and motor circuit connectivity by the LIM-HD protein Isl2. | Lee, Y., et al. 2023. Elife. 12: PMID: 37869988
- Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons. | Renaux, E., et al. 2024. Cell Mol Life Sci. 81: 286. PMID: 38970652
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Islet-2 Antibody (203C5a) | sc-130648 | 100 µg/ml | $339.00 |