Islet-1 Antibody (3B8): sc-101072
- Islet-1 Antibody (3B8) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 100 µg/ml
- raised against recombinant Islet-1 of human origin
- recommended for detection of Islet-1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Islet-1 Antibody (3B8). This work is in progress.
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Islet-1 Antibody (3B8) is a mouse monoclonal IgG2a antibody that detects Islet-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Islet-1 plays a crucial role in various developmental processes, particularly in the embryogenesis of the pancreatic islets of Langerhans and the differentiation of motor neurons in the neural tube. Anti-Islet-1 antibody (3B8) recognizes a transcription factor essential for defining cardiac progenitor cell populations, which are vital for normal cardiac development and asymmetry. Additionally, Islet-1 is involved in the patterning of developing mouse teeth by acting as an activator of Bmp4 expression in specific areas of the stomatodeal epithelium. The protein′s structure, characterized by its amino-terminal LIM domains and carboxy-terminal homeodomain, is significant as Islet-1 interacts with various transcriptional regulators, thereby influencing gene expression patterns critical for organogenesis. Islet-1 monoclonal antibody (3B8) serves as an invaluable tool for researchers studying these developmental pathways and their implications in health and disease.
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Islet-1 Antibody (3B8) References:
- Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development. | Liu, J., et al. 2011. J Biol Chem. 286: 15352-60. PMID: 21388963
- Islet-1 Is essential for pancreatic β-cell function. | Ediger, BN., et al. 2014. Diabetes. 63: 4206-17. PMID: 25028525
- Assessment of DNA synthesis in Islet-1⁺ cells in the adult murine heart. | Weinberger, F., et al. 2015. Biochem Biophys Res Commun. 456: 294-7. PMID: 25450620
- The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis. | Bethea, M., et al. 2019. Am J Physiol Endocrinol Metab. 316: E397-E409. PMID: 30620636
- Islet-1 synergizes with Gcn5 to promote MSC differentiation into cardiomyocytes. | Xu, H., et al. 2020. Sci Rep. 10: 1817. PMID: 32019948
- Analysis of Islet-1, Nkx2.1, Pax6, and Orthopedia in the forebrain of the sturgeon Acipenser ruthenus identifies conserved prosomeric characteristics. | López, JM., et al. 2022. J Comp Neurol. 530: 834-855. PMID: 34547112
- Islet-1 Mesenchymal Stem Cells-Derived Exosome-Incorporated Angiogenin-1 Hydrogel for Enhanced Acute Myocardial Infarction Therapy. | Hu, X., et al. 2022. ACS Appl Mater Interfaces. 14: 36289-36303. PMID: 35920579
- The effects of β-catenin on cardiomyogenesis via Islet-1 and MLIP ubiquitination. | Yan, L., et al. 2022. Exp Biol Med (Maywood). 247: 1956-1967. PMID: 36112854
- Identification of SALL4 Expressing Islet-1+ Cardiovascular Progenitor Cell Clones. | Monteon, A., et al. 2023. Int J Mol Sci. 24: PMID: 36675298
- Islet-1 Is Differentially Expressed Among Neuroendocrine and Non-Neuroendocrine Tumors and Its Potential Diagnostic Implication. | Xiang, Y., et al. 2023. Int J Surg Pathol. 31: 1294-1301. PMID: 37796752
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Islet-1 Antibody (3B8) | sc-101072 | 100 µg/ml | $339.00 |