IRX5 Antibody (IRX5C10G5): sc-81102

IRX5 Antibody (IRX5C10G5) is a mouse monoclonal IgG1 antibody that detects IRX5 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-IRX5 antibody (IRX5C10G5) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important transcription factor. IRX5 protein plays a crucial role in the regulation of embryonic development, particularly in the formation of the central nervous system, where IRX5 is involved in establishing anterior/posterior and dorsal/ventral axis patterning. IRX5 is expressed in the endocardium lining the ventricular and atrial myocardium during heart development, highlighting IRX5′s significance in cardiac morphogenesis. The Iroquois homeobox gene family, to which IRX5 belongs, is known for its distinct expression patterns during development, with members like IRX1 and IRX2 localized to the ventricular septum and IRX3 found in the ventricular trabeculated myocardium. Understanding the expression and function of IRX5 is vital, as disruptions in IRX5 activity can lead to developmental anomalies and contribute to conditions such as cardiomyopathy. IRX5 (IRX5C10G5) antibody enables researchers to gain insights into the molecular mechanisms underlying heart development and the potential implications of IRX5 in cardiac health and disease.

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IRX5 Antibody (IRX5C10G5) References:

1. Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart.  |  Christoffels, VM., et al. 2000. Dev Biol. 224: 263-74. PMID: 10926765
2. Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.  |  Bruneau, BG., et al. 2001. Mol Cell Biol. 21: 1730-6. PMID: 11238910
3. Expression of Irx6 during mouse morphogenesis.  |  Mummenhoff, J., et al. 2001. Mech Dev. 103: 193-5. PMID: 11335133
4. Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes.  |  Ogura, K., et al. 2001. Cytogenet Cell Genet. 92: 320-5. PMID: 11435706
5. Irx1 and Irx2 expression in early lung development.  |  Becker, MB., et al. 2001. Mech Dev. 106: 155-8. PMID: 11472847
6. Expression pattern of Irx1 and Irx2 during mouse digit development.  |  Zülch, A., et al. 2001. Mech Dev. 106: 159-62. PMID: 11472848
7. The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development.  |  Cheng, CW., et al. 2005. Dev Biol. 287: 48-60. PMID: 16182275

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IRX5 Antibody (IRX5C10G5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-IRX5 Antibody (IRX5C10G5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IRX5 Antibody (IRX5C10G5) Specifications

Alternate Product Name: IRX5

Product Clone Name: IRX5C10G5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: IRX5

Epitope Species: human

Product Reactivity/Detection: IRX5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for IRX5 Antibody (IRX5C10G5): N/A