IRF-4 Antibody (MUM1p): sc-56713

IRF-4 Antibody (MUM1p) is a mouse monoclonal IgG1 antibody that detects IRF-4 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-IRF-4 antibody (MUM1p) is available as the non-conjugated form. Interferon regulatory factor-4 (IRF-4) is a crucial member of the IRF family of DNA-binding factors, which play a significant role in regulating both interferon and interferon-inducible genes. IRF-4 is particularly important in the immune system, as IRF-4 is involved in the differentiation and function of various lymphocyte subsets, including T cells and B cells. IRF-4 is known to interact with other proteins, such as PU.1, which is essential for the development of immune cells, and IRF-4 dysregulation has been implicated in multiple myeloma and other hematological malignancies. As a nuclear protein specific to lymphoid cells, IRF-4 acts as a transcriptional activator that binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter, thereby influencing immune responses. The ability of IRF-4 to modulate gene expression in response to cytokines underscores IRF-4′s importance in both normal immune function and disease processes, making IRF-4 (MUM1p) monoclonal antibody a valuable tool for researchers studying immune regulation and related pathologies.

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IRF-4 Antibody (MUM1p) References:

1. Interferon regulatory factors: the next generation.  |  Mamane, Y., et al. 1999. Gene. 237: 1-14. PMID: 10524230
2. Repression of IRF-4 target genes in human T cell leukemia virus-1 infection.  |  Mamane, Y., et al. 2002. Oncogene. 21: 6751-65. PMID: 12360402
3. Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4).  |  Fanzo, JC., et al. 2003. J Exp Med. 197: 303-14. PMID: 12566414
4. Fine tuning of IRF-4 expression by SWAP-70 controls the initiation of plasma cell development.  |  Chopin, M., et al. 2011. Eur J Immunol. 41: 3063-74. PMID: 21728176
5. Expression of IRF-4 and IBP in skin lesions of patients with psoriasis vulgaris.  |  Ni, A., et al. 2012. J Huazhong Univ Sci Technolog Med Sci. 32: 287-290. PMID: 22528235
6. GCN5 is essential for IRF-4 gene expression followed by transcriptional activation of Blimp-1 in immature B cells.  |  Kikuchi, H., et al. 2014. J Leukoc Biol. 95: 399-404. PMID: 24072880
7. Polymorphisms in the IRF-4 gene, asthma and recurrent bronchitis in children.  |  Pinto, LA., et al. 2013. Clin Exp Allergy. 43: 1152-9. PMID: 24074333
8. Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements.  |  Fujita, T., et al. 1988. EMBO J. 7: 3397-405. PMID: 2850164
9. Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system.  |  Tanaka, N., et al. 1993. Mol Cell Biol. 13: 4531-8. PMID: 7687740
10. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.  |  Darnell, JE., et al. 1994. Science. 264: 1415-21. PMID: 8197455
11. Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25.  |  Grossman, A., et al. 1996. Genomics. 37: 229-33. PMID: 8921401
12. Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma.  |  Iida, S., et al. 1997. Nat Genet. 17: 226-30. PMID: 9326949

The preferred IRF-4 antibody is IRF-4 Antibody (F-4): sc-48338.