IRF-2BP1 Antibody (D-5): sc-515314

IRF-2BP1 Antibody (D-5) is a mouse monoclonal IgG1 antibody that detects IRF-2BP1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IRF-2BP1, a 584 amino acid nuclear protein, plays a crucial role as a corepressor of IRF-2, modulating transcriptional activity of interferon regulatory factors and influencing cell growth regulation. IRF-2BP1′s ability to inhibit enhancer activation and basal transcription is significant, as IRF-2BP1 operates independently of histone deacetylation, highlighting a unique regulatory mechanism. Additionally, IRF-2BP1 enhances polyubiquitination of JDP2, a member of the c-Jun family of transcription factors, which is vital for controlling various cellular processes, including apoptosis and proliferation. A C-terminal RING-type zinc finger domain in IRF-2BP1 is essential for interaction with BRCA1 associated protein 1 (BAP1), further underscoring IRF-2BP1′s importance in cellular signaling pathways. Encoded by a gene located on human chromosome 19, which is known for its high gene density, IRF-2BP1 is integral to understanding complex regulatory networks that govern gene expression and cellular responses to external stimuli.

The preferred IRF-2BP1 antibody is IRF-2BP1 Antibody (A-10): sc-373899.