IRAK-M Antibody (XX-6): sc-100389

IRAK-M Antibody (XX-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects the IRAK-M protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-IRAK-M antibody (XX-6) is available as a non-conjugated monoclonal isotype antibody. IRAK-M plays a crucial role in the regulation of immune responses, particularly in the context of Toll-like receptor (TLR) signaling pathways. Unlike other IRAK family members, IRAK-M acts as a negative regulator of TLR signaling, which is essential for preventing excessive inflammation and maintaining immune homeostasis. By inhibiting the activation of downstream signaling pathways, IRAK-M helps to modulate the production of pro-inflammatory cytokines, thereby preventing potential tissue damage caused by an overactive immune response. This regulatory function is particularly important in conditions such as sepsis and chronic inflammatory diseases, where dysregulation of TLR signaling can lead to severe pathological consequences. The restricted expression of IRAK-M to monocytic cells further emphasizes its specialized role in immune regulation, making IRAK-M monoclonal antibody (XX-6) a valuable tool for studying immune responses and related pathologies in human samples.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IRAK-M Antibody (XX-6) References:

1. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.  |  Wesche, H., et al. 1999. J Biol Chem. 274: 19403-10. PMID: 10383454
2. Antigens recognized by autologous antibody in patients with renal-cell carcinoma.  |  Scanlan, MJ., et al. 1999. Int J Cancer. 83: 456-64. PMID: 10508479
3. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.  |  Li, S., et al. 2002. Proc Natl Acad Sci U S A. 99: 5567-72. PMID: 11960013
4. IRAK-M is involved in the pathogenesis of early-onset persistent asthma.  |  Balaci, L., et al. 2007. Am J Hum Genet. 80: 1103-14. PMID: 17503328
5. IL-13 dampens human airway epithelial innate immunity through induction of IL-1 receptor-associated kinase M.  |  Wu, Q., et al. 2012. J Allergy Clin Immunol. 129: 825-833.e2. PMID: 22154382
6. Interleukin-1 receptor-associated kinase M (IRAK-M) promotes human rhinovirus infection in lung epithelial cells via the autophagic pathway.  |  Wu, Q., et al. 2013. Virology. 446: 199-206. PMID: 24074582
7. The Alpha-Melanocyte-Stimulating Hormone Suppresses TLR2-Mediated Functional Responses through IRAK-M in Normal Human Keratinocytes.  |  Ryu, S., et al. 2015. PLoS One. 10: e0136887. PMID: 26309029
8. Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels.  |  Geng, D., et al. 2020. Commun Biol. 3: 306. PMID: 32533049
9. Changes in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study.  |  Xie, X., et al. 2022. J Int Med Res. 50: 3000605221111275. PMID: 36039603
10. NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity.  |  Croston, GE., et al. 1995. J Biol Chem. 270: 16514-7. PMID: 7622454
11. IRAK: a kinase associated with the interleukin-1 receptor.  |  Cao, Z., et al. 1996. Science. 271: 1128-31. PMID: 8599092
12. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.  |  Muzio, M., et al. 1997. Science. 278: 1612-5. PMID: 9374458

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IRAK-M Antibody (XX-6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-IRAK-M Antibody (XX-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IRAK-M Antibody (XX-6) Specifications

Alternate Product Name: IRAK-M

Product Clone Name: XX-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 497-596

Epitope Target: IRAK-M

Epitope Species: human

Product Reactivity/Detection: IRAK-M

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for IRAK-M Antibody (XX-6): N/A