IRAK-1 Antibody (E-5): sc-515512
- IRAK-1 Antibody (E-5) is a mouse monoclonal IgG1 IRAK-1 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 689-712 at the C-terminus of IRAK-1 of human origin
- recommended for detection of IRAK-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- See IRAK-1 (F-4): sc-5288 for IRAK-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for IRAK-1 Antibody (E-5) for WB applications. These reagents are now offered in bundles with IRAK-1 Antibody (E-5) (see ordering information below).
IRAK-1 Antibody (E-5) is a mouse monoclonal IgG1 antibody that detects IRAK-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IRAK-1 antibody (E-5) is available as a non-conjugated monoclonal isotype antibody. IRAK-1 plays a crucial role in the immune response, particularly in the signaling pathways activated by interleukin-1 (IL-1) and toll-like receptors (TLRs). Upon binding of IL-1 to its receptor, IRAK-1 is recruited to the receptor complex, leading to the activation of downstream signaling cascades, including the NF-kB pathway, which is essential for the expression of various pro-inflammatory cytokines. Proper functioning of IRAK-1 is vital for a robust immune response, and dysregulation of IRAK-1 has been implicated in various inflammatory diseases and conditions, making IRAK-1 a significant target for therapeutic intervention. Additionally, IRAK-1 interacts with several other proteins, including TRAF6 and MyD88, which are critical for propagating the signaling cascade initiated by IL-1 and TLRs. Understanding the interactions and functions of IRAK-1 can provide insights into the mechanisms of immune regulation and potential avenues for drug development.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IRAK-1 Antibody (E-5) | sc-515512 | 200 µg/ml | $322.00 | |||
IRAK-1 Antibody (E-5): m-IgG Fc BP-HRP Bundle | sc-541062 | 200 µg Ab; 10 µg BP | $361.00 | |||
IRAK-1 Antibody (E-5): m-IgG1 BP-HRP Bundle | sc-542557 | 200 µg Ab; 20 µg BP | $361.00 | |||
IRAK-1 (E-5) Neutralizing Peptide | sc-515512 P | 100 µg/0.5 ml | $69.00 |