INTS2 Antibody (A-5): sc-514945

INTS2 Antibody (A-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects INTS2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-INTS2 antibody (A-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. INTS2, a 1,204 amino acid single-pass membrane protein, plays a crucial role as a subunit of the integrator complex, which is essential for the transcription and processing of small nuclear RNAs (snRNAs). This complex interacts with the C-terminal domain of RNA polymerase II, facilitating the 3′-end processing of snRNAs such as U1 and U2, which are vital for mRNA splicing and gene expression regulation. Proper functioning of the integrator complex and INTS2 is critical for maintaining gene expression integrity, as dysregulation can lead to various diseases, including cancer. INTS2 (A-5) antibody enables researchers to gain valuable insights into transcription regulation mechanisms and snRNA processing in cellular function.

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INTS2 Antibody (A-5) References:

1. The 3' ends of human pre-snRNAs are produced by RNA polymerase II CTD-dependent RNA processing.  |  Uguen, P. and Murphy, S. 2003. EMBO J. 22: 4544-54. PMID: 12941705
2. Role of the C-terminal domain of RNA polymerase II in U2 snRNA transcription and 3' processing.  |  Jacobs, EY., et al. 2004. Mol Cell Biol. 24: 846-55. PMID: 14701755
3. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.  |  Baillat, D., et al. 2005. Cell. 123: 265-76. PMID: 16239144
4. CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon frequently detected in hepatocellular carcinoma.  |  Inagaki, Y., et al. 2008. Cancer Genet Cytogenet. 180: 30-6. PMID: 18068530
5. Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression.  |  Egloff, S., et al. 2007. Science. 318: 1777-9. PMID: 18079403
6. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.  |  Richard, DJ., et al. 2008. Nature. 453: 677-81. PMID: 18449195
7. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response.  |  Li, Y., et al. 2009. J Biol Chem. 284: 23525-31. PMID: 19605351
8. SOSS complexes participate in the maintenance of genomic stability.  |  Huang, J., et al. 2009. Mol Cell. 35: 384-93. PMID: 19683501
9. INTS3 controls the hSSB1-mediated DNA damage response.  |  Skaar, JR., et al. 2009. J Cell Biol. 187: 25-32. PMID: 19786574
10. Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites.  |  Lim, B., et al. 2016. Oncotarget. 7: 8055-66. PMID: 26811494
11. The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells.  |  Zhang, Y., et al. 2019. Cell Rep. 27: 987-996.e3. PMID: 31018143
12. Prognostic Value Estimation of BRIP1 in Breast Cancer by Exploiting Transcriptomics Data Through Bioinformatics Approaches.  |  Khan, U. and Khan, MS. 2021. Bioinform Biol Insights. 15: 11779322211055892. PMID: 34840500

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-INTS2 Antibody (A-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-INTS2 Antibody (A-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

INTS2 Antibody (A-5) Specifications

Alternate Product Name: INTS2

Product Clone Name: A-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 47-109

Epitope Target: INTS2

Epitope Species: human

Product Reactivity/Detection: INTS2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for INTS2 Antibody (A-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin