Intelectin-1/2 Antibody (3G1B3): sc-130923

Intelectin-1/2 Antibody (3G1B3) is a mouse monoclonal IgG antibody that detects Intelectin-1/2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Intelectin-1/2 antibody (3G1B3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Intelectin-1, also known as ITLN1, INTL, Omentin, or LFR, is a 313 amino acid protein characterized by a fibrinogen C-terminal domain and can be either secreted or lipid-anchored to the cell membrane. Intelectin-1 is predominantly expressed in the small intestine and adipose tissue, with lower expression levels found in the testis, heart, pancreas, colon, and skeletal muscle. This protein exists as a disulfide-linked homotrimer and plays a crucial role in enhancing insulin-stimulated glucose uptake, which is vital for maintaining glucose homeostasis and energy balance in the body. Additionally, Intelectin-1 participates in the immune response against microorganisms, highlighting its importance in both metabolic regulation and host defense. Intelectin-2, which shares 85% amino acid identity with Intelectin-1, is also a secreted protein with a similar structure but is exclusively found in the small intestine, suggesting a specialized role in intestinal immunity.

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Intelectin-1/2 Antibody (3G1B3) References:

1. Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall.  |  Tsuji, S., et al. 2001. J Biol Chem. 276: 23456-63. PMID: 11313366
2. Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE).  |  Wali, A., et al. 2005. Lung Cancer. 48: 19-29. PMID: 15777968
3. Mammalian lactoferrin receptors: structure and function.  |  Suzuki, YA., et al. 2005. Cell Mol Life Sci. 62: 2560-75. PMID: 16261254
4. Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue.  |  Schäffler, A., et al. 2005. Biochim Biophys Acta. 1732: 96-102. PMID: 16386808
5. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.  |  Yang, RZ., et al. 2006. Am J Physiol Endocrinol Metab. 290: E1253-61. PMID: 16531507
6. Omentin plasma levels and gene expression are decreased in obesity.  |  de Souza Batista, CM., et al. 2007. Diabetes. 56: 1655-61. PMID: 17329619
7. Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose.  |  Tan, BK., et al. 2008. Diabetes. 57: 801-8. PMID: 18174521
8. Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion.  |  Tsuji, S., et al. 2010. Br J Cancer. 103: 517-23. PMID: 20628387
9. Recognition of microbial glycans by human intelectin-1.  |  Wesener, DA., et al. 2015. Nat Struct Mol Biol. 22: 603-10. PMID: 26148048
10. Human Intelectin-1 Promotes Cellular Attachment and Neutrophil Killing of Streptococcus pneumoniae in a Serotype-Dependent Manner.  |  Andresen, S., et al. 2022. Infect Immun. 90: e0068221. PMID: 35499339

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Intelectin-1/2 Antibody (3G1B3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Intelectin-1/2 Antibody (3G1B3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Intelectin-1/2 Antibody (3G1B3) Specifications

Alternate Product Name: Intelectin-1/2

Product Clone Name: 3G1B3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG kappa light chain

Amino Acids:

Epitope Target: Intelectin-1

Epitope Species: human

Product Reactivity/Detection: Intelectin-1 and Intelectin-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Intelectin-1/2 Antibody (3G1B3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin