Integrin β6/ITGB6 Antibody (4C3): sc-293194
- Integrin β6/ITGB6 Antibody (4C3) is a mouse monoclonal IgG2a κ Integrin β6/ITGB6 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against amino acids 604-707 of Integrin β6 of human origin
- recommended for detection of Integrin β6 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin β6/ITGB6 Antibody (4C3). This work is in progress.
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Integrin β6 Antibody (4C3) is a mouse monoclonal IgG2a kappa light chain antibody that detects Integrin beta 6 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Integrin beta 6 antibody (4C3) is available as a non-conjugated isotype antibody. Integrin beta 6 protein plays a crucial role in cell adhesion and signaling, functioning as a receptor that mediates interactions between cells and the extracellular matrix. Integrin beta 6 is primarily located on the cell surface, where heterodimer formation with various alpha subunits contributes to creating more than 20 different integrin receptors. Integrin beta 6 is particularly important in processes such as wound healing and tissue repair, facilitating the binding of cells to extracellular matrix components like fibronectin and collagen. Integrin beta 6 is involved in signaling pathways that regulate cell growth, differentiation, and migration, making Integrin beta 6 a key player in both normal physiological processes and pathological conditions, including cancer metastasis. Anti-Integrin beta 6 antibody (4C3) enables valuable insights into the functional dynamics of Integrin beta 6 and its role in cellular interactions.
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Integrin β6/ITGB6 Antibody (4C3) References:
- The cytoplasmic extension of the integrin β6 subunit regulates epithelial-to-mesenchymal transition. | Lee, C., et al. 2014. Anticancer Res. 34: 659-64. PMID: 24510996
- Clinical significance of integrin β6 as a tumor recurrence factor in follicular thyroid carcinoma. | Zhuang, ZN., et al. 2015. Head Neck. 37: 1439-47. PMID: 24844802
- Cloning and characterization of the human integrin β6 gene promoter. | Xu, M., et al. 2015. PLoS One. 10: e0121439. PMID: 25816241
- Integrin β6 serves as an immunohistochemical marker for lymph node metastasis and promotes cell invasiveness in cholangiocarcinoma. | Li, Z., et al. 2016. Sci Rep. 6: 30081. PMID: 27440504
- Identification of integrin β6 gene promoter and analysis of its transcription regulation in colon cancer cells. | Niu, W., et al. 2020. World J Gastrointest Oncol. 12: 526-534. PMID: 32461784
- Integrin-β6 Serves as a Potential Prognostic Serum Biomarker for Gastric Cancer. | Li, Z., et al. 2021. Front Oncol. 11: 770997. PMID: 34796117
- FOXO1 inhibits FSL-1 regulation of integrin β6 by blocking STAT3 binding to the integrin β6 gene promoter. | Xu, M., et al. 2022. Front Cell Infect Microbiol. 12: 998693. PMID: 36299623
- Integrin β6 mediates epithelial-mesenchymal transition in diabetic kidney disease. | Li, X., et al. 2023. Mol Cell Endocrinol. 572: 111955. PMID: 37187284
- Integrin β6 deficiency protects mice from experimental colitis and colitis-associated carcinoma by altering macrophage polarization. | Sun, Q., et al. 2023. Front Oncol. 13: 1190229. PMID: 37223685
- Integrin β6/Annexin A2 axis triggers autophagy to orchestrate hepatocellular carcinoma radioresistance. | Gao, Y., et al. 2024. Cell Death Differ.. PMID: 39533071
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin β6/ITGB6 Antibody (4C3) | sc-293194 | 100 µg/ml | $316.00 |