Integrin β6/ITGB6 Antibody (C5): sc-517598

Integrin β6 Antibody (C5) is a mouse monoclonal IgG2b kappa light chain antibody that detects human Integrin β6 by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Integrin β6 antibody (C5) is available in non-conjugated form. Integrins, including Integrin β6, are crucial for mediating cell adhesion and play a significant role in various cellular processes. The structure of Integrin β6 consists of a unique combination of α and β subunits that form a heterodimer, allowing interaction with specific ligands in the extracellular matrix, such as fibronectin and vitronectin. This structural configuration facilitates cell adhesion and enables signal transduction that influences cell behavior, including growth, differentiation, and migration. Integrin β6 clustering and activation in response to ligand binding drives cellular signaling pathways, making Integrin β6 vital for wound healing and tissue repair. Anti-Integrin β6 antibody (C5) enables researchers to investigate cell adhesion mechanisms and integrin functions in health and disease.

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Integrin β6/ITGB6 Antibody (C5) References:

1. Vascular endothelial growth factor receptor-1 is deposited in the extracellular matrix by endothelial cells and is a ligand for the alpha 5 beta 1 integrin.  |  Orecchia, A., et al. 2003. J Cell Sci. 116: 3479-89. PMID: 12865438
2. Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.  |  Mould, AP., et al. 2003. J Biol Chem. 278: 51622-9. PMID: 14532288
3. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
4. Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation.  |  Kaabeche, K., et al. 2005. J Cell Sci. 118: 1223-32. PMID: 15728256
5. Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells.  |  Kuwada, SK., et al. 2005. J Biol Chem. 280: 19027-35. PMID: 15757908
6. Transforming growth factor-β1 and lysophosphatidic acid activate integrin β6 gene promoter in Hep-3B cells.  |  Xu, R., et al. 2018. Oncol Lett. 16: 439-446. PMID: 29930716
7. Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Cell Invasion through Integrin β6 Upregulation in Colorectal Cancer.  |  Sun, Q., et al. 2020. Oxid Med Cell Longev. 2020: 8032187. PMID: 32855767
8. Expression of Integrin β6 and HAX-1 Correlates with Aggressive Features and Poor Prognosis in Esophageal Squamous Cell Carcinoma.  |  Li, F., et al. 2020. Cancer Manag Res. 12: 9599-9608. PMID: 33061645
9. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
10. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
11. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
12. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin β6/ITGB6 Antibody (C5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin β6/ITGB6 Antibody (C5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin β6/ITGB6 Antibody (C5) Specifications

Alternate Product Name: Integrin β6

Product Clone Name: C5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: Integrin β6

Epitope Species: human

Product Reactivity/Detection: Integrin β6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 5% glycerol

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Integrin β6/ITGB6 Antibody (C5): N/A