Integrin β2/ITGB2/CD18 Antibody (3H1041): sc-71405

Integrin β2 Antibody (3H1041) is a rat monoclonal IgG2a antibody that detects Integrin β2 in mouse samples through immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM) applications. Integrin β2 is a crucial component of the integrin family, which consists of heterodimers formed by noncovalently associated transmembrane α and β subunits. Specifically, anti-Integrin β2 antibody (3H1041) pairs with various α subunits to form receptors that play a vital role in cell adhesion and signaling. Integrin β2 is predominantly located on the cell surface, where Integrin β2 interacts with ligands in the extracellular matrix, such as Fibronectin and Collagen, as well as with counterreceptors on adjacent cells, facilitating cellular communication and aggregation. Proper functioning of Integrin β2 is essential for numerous biological processes, including immune response, wound healing, and tissue repair, as Integrin β2 mediates the attachment of leukocytes to endothelial cells during inflammation. Furthermore, activation of Integrin β2 is influenced by clustering and ligand binding, which are critical for initiating downstream signaling pathways that regulate cell growth, differentiation, and migration. Integrin β2 (3H1041) monoclonal antibody serves as an invaluable tool for researchers studying these complex cellular interactions and the underlying mechanisms of various physiological and pathological conditions.

The preferred Integrin β2/ITGB2/CD18 antibody is Integrin β2/ITGB2/CD18 Antibody (CTB104): sc-8420.