Integrin β1/ITGB1 Antibody (K-20): sc-18887

Integrin β1 Antibody (K-20) is a mouse monoclonal IgG2a light chain antibody that detects Integrin β1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-Integrin β1 antibody (K-20) is available in both conjugated and non-conjugated forms, providing versatility for various experimental needs. Integrin β1 is a crucial component of the integrin family, which consists of heterodimers formed by noncovalently associated transmembrane α and β subunits. The presence of 16 α and 8 β subunits allows for the formation of over 20 distinct integrin receptors, each playing a vital role in cell adhesion and communication. Notably, Integrin β1 interacts with ligands such as fibronectin, collagen, and vitronectin, which are essential components of the extracellular matrix. This interaction facilitates cell adhesion and triggers intracellular signaling pathways that influence various biological processes, including cell growth, differentiation, migration, and apoptosis. Integrin β1′s ability to bind to soluble ligands and counterreceptors on adjacent cells, such as intracellular adhesion molecules (ICAMs), further underscores its importance in cellular aggregation and tissue integrity. Anti-Integrin β1 antibody (K-20) enables researchers to explore the multifaceted roles of Integrin β1 in cellular dynamics and its implications in health and disease.

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Integrin β1/ITGB1 Antibody (K-20) References:

1. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
2. Beta-1 integrin is important for the structural maintenance and homeostasis of differentiating fiber cells.  |  Scheiblin, DA., et al. 2014. Int J Biochem Cell Biol. 50: 132-45. PMID: 24607497
3. β1-integrin-dependent migration of microglia in response to neuron-released α-synuclein.  |  Kim, C., et al. 2014. Exp Mol Med. 46: e91. PMID: 24743837
4. EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation.  |  Zhang, L., et al. 2022. Nat Commun. 13: 2543. PMID: 35538070
5. The characteristics and the multiple functions of integrin β1 in human cancers.  |  Sun, L., et al. 2023. J Transl Med. 21: 787. PMID: 37932738
6. Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility.  |  Balzac, F., et al. 1994. J Cell Biol. 127: 557-65. PMID: 7523423
7. Novel isoform of beta 1 integrin expressed in skeletal and cardiac muscle.  |  Zhidkova, NI., et al. 1995. Biochem Biophys Res Commun. 214: 279-85. PMID: 7545396
8. Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit.  |  Balzac, F., et al. 1993. J Cell Biol. 121: 171-8. PMID: 7681433
9. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
10. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
11. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
12. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin β1/ITGB1 Antibody (K-20) has 35 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin β1/ITGB1 Antibody (K-20) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin β1/ITGB1 Antibody (K-20) Specifications

Alternate Product Name: CD29

Product Clone Name: K-20

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: Integrin β1

Epitope Species: human

Product Reactivity/Detection: Integrin β1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 35 citations in various scientific publications

Available Conjugates/Forms for Integrin β1/ITGB1 Antibody (K-20): AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein