Integrin β1/ITGB1 Antibody (2Q837): sc-71385

Integrin β1 Antibody (2Q837) is a mouse monoclonal IgG1 antibody that detects Integrin β1 in human samples through various applications including western blotting (WB) (non-reducing), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin β1 plays a crucial role in cell adhesion and signaling, functioning as a key component of the extracellular matrix interaction that facilitates communication between cells and their environment. Integrin β1 is primarily located on the cell surface, where Integrin β1 forms heterodimers with various α subunits, allowing binding to ligands such as fibronectin and collagen. Proper localization of Integrin β1 is essential for maintaining tissue integrity and facilitating cellular responses to external stimuli. Integrin β1′s ability to cluster and interact with other proteins is vital for initiating signaling cascades that regulate critical biological processes, including cell migration, proliferation, and survival. Anti-Integrin β1 antibody (2Q837) enables researchers to gain insights into the dynamics of cell adhesion and the underlying mechanisms of various diseases, making anti-Integrin β1 antibody (2Q837) an invaluable tool for studies in cell biology and pathology.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Integrin β1/ITGB1 Antibody (2Q837) References:

1. Control of interstitial fluid pressure: role of beta1-integrins.  |  Reed, RK., et al. 2001. Semin Nephrol. 21: 222-30. PMID: 11320485
2. Galectin-1 interacts with beta-1 subunit of integrin.  |  Moiseeva, EP., et al. 2003. Biochem Biophys Res Commun. 310: 1010-6. PMID: 14550305
3. Threonine 788 in integrin subunit beta1 regulates integrin activation.  |  Nilsson, S., et al. 2006. Exp Cell Res. 312: 844-53. PMID: 16405888
4. The behavior of osteoblast-like cells on various substrates with functional blocking of integrin-beta1 and integrin-beta3.  |  Siebers, MC., et al. 2008. J Mater Sci Mater Med. 19: 861-8. PMID: 17665129
5. Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability.  |  Abraham, S., et al. 2008. Circ Res. 102: 562-70. PMID: 18202311
6. beta1 integrin/FAK/ERK signalling pathway is essential for human fetal islet cell differentiation and survival.  |  Saleem, S., et al. 2009. J Pathol. 219: 182-92. PMID: 19544355
7. Role of Site-Specific Glycosylation in the I-Like Domain of Integrin β1 in Small Extracellular Vesicle-Mediated Malignant Behavior and FAK Activation.  |  Cao, L., et al. 2021. Int J Mol Sci. 22: PMID: 33578954
8. Diallyl Trisulfide, a Major Bioactive Constituent of Garlic, Promotes Colonic Mucosal Healing in Ulcerative Colitis through Accelerating Focal Adhesion Assembly and Consequent Epithelial Cell Migration via the Rab21-Integrin β1-Fak Pathway.  |  Zhang, Y., et al. 2023. Mol Nutr Food Res. 67: e2200784. PMID: 36938915
9. An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold.  |  Wong, W., et al. 2023. PLoS Biol. 21: e3002212. PMID: 37540708
10. Up-regulation of a novel integrin alpha-chain (alpha mt) on human fetal myotubes.  |  Gullberg, D., et al. 1995. Dev Dyn. 204: 57-65. PMID: 8563026

The preferred Integrin β1/ITGB1 antibody is Integrin β1/ITGB1 Antibody (K-20): sc-18887.