Integrin β1/ITGB1 Antibody (12G10): sc-59827

Integrin β1 Antibody (12G10) is a mouse monoclonal IgG1 kappa light chain antibody that detects human Integrin β1 by western blotting (WB) (non-reducing), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-Integrin β1 antibody (12G10) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Integrin β1 is a crucial component of integrin receptors, which are heterodimers formed by the noncovalent association of α and β subunits. The presence of 16 α and 8 β subunits allows for the formation of over 20 distinct integrin receptors, each playing a vital role in cell adhesion and communication with the extracellular matrix. Integrin β1 interacts with ligands such as fibronectin, collagen, and vitronectin, facilitating cell attachment and signaling. This interaction is essential for various biological processes, including cell growth, differentiation, migration, and apoptosis. Integrin β1 binds to soluble ligands and counterreceptors on adjacent cells, such as intracellular adhesion molecules (ICAMs), underscoring its importance in cellular aggregation and tissue integrity. The activation of integrin-mediated responses requires both receptor clustering and ligand occupancy, highlighting the intricate regulatory mechanisms that govern cell behavior. Integrin β1 (12G10) monoclonal antibody serves as an invaluable tool for researchers studying the complex roles of integrins in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin β1/ITGB1 Antibody (12G10) has 24 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin β1/ITGB1 Antibody (12G10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin β1/ITGB1 Antibody (12G10) Specifications

Alternate Product Name: CD29

Product Clone Name: 12G10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Integrin β1

Epitope Species: human

Product Reactivity/Detection: Integrin β1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB (non-reducing), IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 24 citations in various scientific publications

Available Conjugates/Forms for Integrin β1/ITGB1 Antibody (12G10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Integrin β1/ITGB1 antibody is Integrin β1/ITGB1 Antibody (K-20): sc-18887.